Understanding clinical and immunological features associated with Pseudomonas and Staphylococcus keratitis

Gauri Shankar Shrestha*, Ajay Kumar Vijay, Fiona Stapleton, Fiona L. Henriquez, Nicole Carnt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Pseudomonas aeruginosa and Staphylococcus aureus are the two dominant Gram-negative and -positive species, respectively, isolated from patients with contact lens-related bacterial keratitis. The clinical features of bacterial keratitis vary, such that timely differential diagnosis can be challenging, which may cause a delay in diagnosis resulting in poorer outcome. This review aims to explore the current understanding of clinical and immunological features associated with contact lens-related P. aeruginosa and S. aureus keratitis based on currently available evidence.

Firstly, the review characterises contact lens-related P. aeruginosa and S. aureus keratitis, based on clinical features and prognostic factors. Secondly, the review describes the primary immune response associated with a bacterial infection in in-vivo non-scratch contact lens-wearing animal models, colonised by bacteria on contact lens and topical administration of bacteria on the cornea. Finally, the review discusses the role of macrophage inflammatory protein-2 (MIP-2) and intercellular adhesion molecule (ICAM-1) in neutrophil recruitment based on both in-vivo scratch models of bacterial keratitis and bacterial challenged in cell culture models.
Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalContact Lens and Anterior Eye
Volume44
Issue number1
Early online date8 Dec 2020
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • contact lens
  • cornea
  • Pseudomonas aeruginosa
  • Staphylococcus aureus
  • neutrophil
  • MIP-2
  • ICAM-1
  • keratitis

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