Tribbles and arthritis: what are the links?

Andrew D. Rowan, Gary J. Litherland

Research output: Contribution to journalArticle

3 Citations (Scopus)


The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation-related pathologies such as diabetes, multiple sclerosis and cancer, very little is known about their roles in arthritis. The present review discusses current knowledge of the impact of TRIB on pro-inflammatory cellular mechanisms and pathways known to be important in the pathogenesis of RA and OA.
Original languageEnglish
Pages (from-to)1051-1056
JournalBiochemical Society Transactions
Publication statusPublished - Oct 2015


  • arthritis
  • inflammation
  • matrix metalloproteinases (MMPs)
  • signalling
  • tribbles


  • 1 Participation in conference

Tribbles Pseudokinases

Gary Litherland (Chair)

23 Apr 2015

Activity: Participating in or organising an eventParticipation in conference

Research Output

  • 3 Citations
  • 9 Article
  • 3 Meeting Abstract

Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation

Chan, C. M., Macdonald, C. D., Litherland, G., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N. & Rowan, A. D., 12 Dec 2016, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Open Access
  • 17 Citations (Scopus)

    Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

    Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., Young, D. A. & Rowan, A. D., Aug 2014, In : Arthritis & Rheumatology. 66, 8, p. 2175-2187

    Research output: Contribution to journalArticle

    Open Access
    15 Citations (Scopus)

    The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes

    Baker, J., Litherland, G. J. & Rowan, A. D., Apr 2013, In : Rheumatology. 52, S1, p. S49-S49 1 p.

    Research output: Contribution to journalMeeting Abstract

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