Tribbles and arthritis: what are the links?

Andrew D. Rowan, Gary J. Litherland

Research output: Contribution to journalArticle

Abstract

The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation-related pathologies such as diabetes, multiple sclerosis and cancer, very little is known about their roles in arthritis. The present review discusses current knowledge of the impact of TRIB on pro-inflammatory cellular mechanisms and pathways known to be important in the pathogenesis of RA and OA.
Original languageEnglish
Pages (from-to)1051-1056
JournalBiochemical Society Transactions
Volume43
DOIs
Publication statusPublished - Oct 2015

Keywords

  • arthritis
  • inflammation
  • matrix metalloproteinases (MMPs)
  • signalling
  • tribbles

Cite this

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Tribbles and arthritis: what are the links? / Rowan, Andrew D.; Litherland, Gary J.

In: Biochemical Society Transactions, Vol. 43, 10.2015, p. 1051-1056.

Research output: Contribution to journalArticle

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