Time course of changes in immuneoendocrine markers following an international rugby game

Brian Cunniffe, Andrew J. Hore, Dean M. Whitcombe, Ken P. Jones, Julien S. Baker, Bruce Davies

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Intense exercise is known to cause temporary impairments in immune function. Few studies, however, have investigated the effects of intense competitive exercise on immunoendocrine variables in elite team sport athletes. The aim of this study was to evaluate the time course of changes in selected immunoendocrine and inflammatory markers following an international rugby union game. Blood samples were taken from players (n = 10) on camp entry, the morning of the game (pre), immediately after (post) and 14 and 38 h into a passive recovery period. Players lost 1.4 ± 0.2 kg of body mass during the game (ambient conditions, 11°C, 45% RH). An acute phase inflammatory response was observed as reflected through immediate increases in serum cortisol and IL-6 (post) followed by delayed increases in serum creatine kinase (CK; 14 h) activity and C-reactive protein (CRP; 38 h); P < 0.05. Decreases in the number of circulating T lympocytes, NK cells and bacteria-stimulated neutrophil degranulation were also observed post-exercise (P < 0.05), indicative of decreased host immune protection. Following a large decrease in serum testosterone to cortisol (T/C) ratio immediately post and 14 h after exercise, T/C values then increased above those observed at camp entry 38 h into recovery (P < 0.05). This rebound anabolic stimulus may represent a physiological requirement for recovery following intense tissue damage resulting from game collisions. The findings also suggest that a game of international rugby elicits disturbances in host immunity, which last up 38 h into the recovery period.
Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalEuropean Journal of Applied Physiology
Volume108
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Fingerprint

Football
Exercise
Hydrocortisone
Serum
Acute-Phase Reaction
Creatine Kinase
Natural Killer Cells
Athletes
C-Reactive Protein
Sports
Testosterone
Immunity
Interleukin-6
Neutrophils
Bacteria

Keywords

  • rugby
  • immune
  • collisions
  • tissue damage

Cite this

Cunniffe, B., Hore, A. J., Whitcombe, D. M., Jones, K. P., Baker, J. S., & Davies, B. (2010). Time course of changes in immuneoendocrine markers following an international rugby game. European Journal of Applied Physiology, 108(1), 113-122. https://doi.org/10.1007/s00421-009-1200-9
Cunniffe, Brian ; Hore, Andrew J. ; Whitcombe, Dean M. ; Jones, Ken P. ; Baker, Julien S. ; Davies, Bruce. / Time course of changes in immuneoendocrine markers following an international rugby game. In: European Journal of Applied Physiology. 2010 ; Vol. 108, No. 1. pp. 113-122.
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Cunniffe, B, Hore, AJ, Whitcombe, DM, Jones, KP, Baker, JS & Davies, B 2010, 'Time course of changes in immuneoendocrine markers following an international rugby game', European Journal of Applied Physiology, vol. 108, no. 1, pp. 113-122. https://doi.org/10.1007/s00421-009-1200-9

Time course of changes in immuneoendocrine markers following an international rugby game. / Cunniffe, Brian; Hore, Andrew J.; Whitcombe, Dean M.; Jones, Ken P.; Baker, Julien S.; Davies, Bruce.

In: European Journal of Applied Physiology, Vol. 108, No. 1, 01.01.2010, p. 113-122.

Research output: Contribution to journalArticle

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