Therapeutic targets for the treatment of chronic cough

N.A. Roe; F.T. Lundy; G.J. Litherland; L.P.A. McGarvey

doi:10.1007/s40136-019-00239-9

Therapeutic targets for the treatment of chronic cough

N.A. Roe
, F.T. Lundy
, G.J. Litherland
, L.P.A. McGarvey

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

206 Downloads (Pure)

Abstract

Purpose of Review
Chronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Recent Findings
Chronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough.

Summary
In this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.

Original language	English
Pages (from-to)	116-128
Number of pages	13
Journal	Current Otorhinolaryngology Reports
Volume	7
Issue number	2
Early online date	2 May 2019
DOIs	https://doi.org/10.1007/s40136-019-00239-9
Publication status	Published - 30 Jun 2019

Keywords

Cough
Cough receptor
Pharmacological Targets
Novel
Ion channel

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10.1007/s40136-019-00239-9Licence: CC BY

2019 04 12 Roe Therapeutic finalFinal published version, 473 KBLicence: CC BY

Cite this

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T1 - Therapeutic targets for the treatment of chronic cough

AU - Roe, N.A.

AU - Lundy, F.T.

AU - Litherland, G.J.

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PY - 2019/6/30

Y1 - 2019/6/30

N2 - Purpose of Review Chronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Recent Findings Chronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough. Summary In this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.

AB - Purpose of Review Chronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Recent Findings Chronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough. Summary In this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.

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KW - Ion channel

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JO - Current Otorhinolaryngology Reports

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Therapeutic targets for the treatment of chronic cough

Abstract

Keywords

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