Therapeutic targets for the treatment of chronic cough

N.A. Roe, F.T. Lundy, G.J. Litherland, L.P.A. McGarvey

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
171 Downloads (Pure)

Abstract

Purpose of Review
Chronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Recent Findings
Chronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough.

Summary
In this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.
Original languageEnglish
Pages (from-to)116-128
Number of pages13
JournalCurrent Otorhinolaryngology Reports
Volume7
Issue number2
Early online date2 May 2019
DOIs
Publication statusPublished - 30 Jun 2019

Keywords

  • Cough
  • Cough receptor
  • Pharmacological Targets
  • Novel
  • Ion channel

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