The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes

Jonathan Baker, Gary J. Litherland, Andrew D. Rowan

Research output: Contribution to journalMeeting Abstract

Research Output

Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation

Chan, C. M., Macdonald, C. D., Litherland, G., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N. & Rowan, A. D., 12 Dec 2016, In : Journal of Biological Chemistry.

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Open Access
17 Citations (Scopus)

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

Zhang, Q., Hui, W., Litherland, G. J., Barter, M. J., Davidson, R., Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. & Young, D. A., Nov 2008, In : Annals of the Rheumatic Diseases. 67, 11, p. 1633-1641

Research output: Contribution to journalArticle

74 Citations (Scopus)

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., Young, D. A. & Rowan, A. D., Aug 2014, In : Arthritis & Rheumatology. 66, 8, p. 2175-2187

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Open Access
15 Citations (Scopus)

HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes

Barter, M. J., Pybus, L., Litherland, G. J., Rowan, A. D., Clark, I. M., Edwards, D. R., Cawston, T. E. & Young, D. A., Sep 2010, In : Matrix Biology. 29, 7, p. 602-612

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57 Citations (Scopus)

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

Hui, W., Litherland, G. J., Elias, M. S., Kitson, G. I., Cawston, T. E., Rowan, A. D. & Young, D. A., Mar 2012, In : Annals of the Rheumatic Diseases. 71, 3, p. 455-62 8 p.

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119 Citations (Scopus)

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway

Hui, W., Litherland, G. J., Jefferson, M., Barter, M. J., Elias, M. S., Cawston, T. E., Rowan, A. D. & Young, D. A., Nov 2010, In : Rheumatology. 49, 11, p. 2043-2053

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30 Citations (Scopus)

Metalloproteases as potential therapeutic targets in arthritis treatment

Rowan, A. D., Litherland, G. J., Hui, W. & Milner, J. M., Jan 2008, In : Expert Opinion on Therapeutic Targets. 12, 1, p. 1-18 18 p.

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45 Citations (Scopus)

Protein Kinase C Isoforms zeta and iota Mediate Collagenase Expression and Cartilage Destruction via STAT3-and ERK-dependent c-fos Induction

Litherland, G. J., Elias, M. S., Hui, W., Macdonald, C. D., Catterall, J. B., Barter, M. J., Farren, M. J., Jefferson, M. & Rowan, A. D., 16 Jul 2010, In : Journal of Biological Chemistry. 285, 29, p. 22414-22425

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Open Access
41 Citations (Scopus)

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Baker, J., Falconer, A., Wilkinson, D. J., Europe-Finner, G. N., Litherland, G. & Rowan, A. D., 13 Apr 2018, In : PLoS ONE. 13, 4, 19 p., e0195864.

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Open Access
9 Citations (Scopus)

Role of protein kinase C isoforms in collagenase induction and cartilage degradation

Rowan, A. D. & Litherland, G., 2009, In : Osteoarthritis and Cartilage. 17, Supplement 1, p. S146

Research output: Contribution to journalMeeting Abstract

Open Access

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent

Litherland, G. J., Dixon, C., Lakey, R. L., Robson, T., Jones, D., Young, D. A., Cawston, T. E. & Rowan, A. D., 23 May 2008, In : Journal of Biological Chemistry. 283, 21, p. 14221-14229 9 p.

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Open Access
36 Citations (Scopus)

Tribbles and arthritis: what are the links?

Rowan, A. D. & Litherland, G. J., Oct 2015, In : Biochemical Society Transactions. 43, p. 1051-1056

Research output: Contribution to journalArticle

3 Citations (Scopus)