The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes

2018

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Baker, J., Falconer, A., Wilkinson, D. J., Europe-Finner, G. N., Litherland, G. & Rowan, A. D., 13 Apr 2018, In: PLoS ONE. 13, 4, 19 p., e0195864.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

2017

Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation

Chan, C. M., Macdonald, C. D., Litherland, G., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N. & Rowan, A. D., 3 Feb 2017, In: Journal of Biological Chemistry. 292, 5, p. 1625-1636 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

2015

Tribbles and arthritis: what are the links?

Rowan, A. D. & Litherland, G. J., Oct 2015, In: Biochemical Society Transactions. 43, p. 1051-1056

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2014

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., Young, D. A. & Rowan, A. D., Aug 2014, In: Arthritis & Rheumatology. 66, 8, p. 2175-2187 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

2012

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

Hui, W., Litherland, G. J., Elias, M. S., Kitson, G. I., Cawston, T. E., Rowan, A. D. & Young, D. A., Mar 2012, In: Annals of the Rheumatic Diseases. 71, 3, p. 455-62 8 p.

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

2010

HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes

Barter, M. J., Pybus, L., Litherland, G. J., Rowan, A. D., Clark, I. M., Edwards, D. R., Cawston, T. E. & Young, D. A., Sept 2010, In: Matrix Biology. 29, 7, p. 602-612

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway

Hui, W., Litherland, G. J., Jefferson, M., Barter, M. J., Elias, M. S., Cawston, T. E., Rowan, A. D. & Young, D. A., Nov 2010, In: Rheumatology. 49, 11, p. 2043-2053

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Protein Kinase C Isoforms zeta and iota Mediate Collagenase Expression and Cartilage Destruction via STAT3-and ERK-dependent c-fos Induction

Litherland, G. J., Elias, M. S., Hui, W., Macdonald, C. D., Catterall, J. B., Barter, M. J., Farren, M. J., Jefferson, M. & Rowan, A. D., 16 Jul 2010, In: Journal of Biological Chemistry. 285, 29, p. 22414-22425

Research output: Contribution to journal › Article › peer-review

Open Access

45 Citations (Scopus)

2009

Role of protein kinase C isoforms in collagenase induction and cartilage degradation

Rowan, A. D. & Litherland, G., 2009, In: Osteoarthritis and Cartilage. 17, Supplement 1, p. S146

Research output: Contribution to journal › Meeting Abstract

Open Access

2008

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

Zhang, Q., Hui, W., Litherland, G. J., Barter, M. J., Davidson, R., Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. & Young, D. A., Nov 2008, In: Annals of the Rheumatic Diseases. 67, 11, p. 1633-1641

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Metalloproteases as potential therapeutic targets in arthritis treatment

Rowan, A. D., Litherland, G. J., Hui, W. & Milner, J. M., Jan 2008, In: Expert Opinion on Therapeutic Targets. 12, 1, p. 1-18 18 p.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent

Litherland, G. J., Dixon, C., Lakey, R. L., Robson, T., Jones, D., Young, D. A., Cawston, T. E. & Rowan, A. D., 23 May 2008, In: Journal of Biological Chemistry. 283, 21, p. 14221-14229 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Citations (Scopus)

The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes

Research output

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