The role of multimicronutrient supplementation in pediatric HIV management in Nigeria: a randomized controlled study

Regina Esiovwa*, Jean Rankin, Agatha David, Elizabeth Disu, Agatha Wapmuk, Olufemi Amoo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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We aimed to compare the immunologic and hematologic effects of 3 multimicronutrient supplements in human immunodeficiency virus–positive children in Lagos, Nigeria.

This double-blind, randomized controlled study included 190 children, aged 5–12 years, in Lagos, Nigeria. Sixty-four, 63, and 63 participants were assigned to multimicronutrient group A, B, or C, respectively, for 6 months. Supplements A, B, and C contained 7 micronutrients at the recommended daily allowance (RDA) (comparable to standard-of-care multivitamin), 22 micronutrients at the RDA, and 22 micronutrients at 3 times the recommended daily allowance (3RDA), respectively. Using paired sample t tests and factorial repeat-measures analysis of variance (ANOVA), within- and between-group changes in CD4 count and hemoglobin levels were evaluated after 6 months.

After 6 months of supplementation, paired-sample t test showed that CD4 cell count did not significantly differ from baseline for all 3 groups. Between-subject effect also did not significantly differ in the 3 groups after 6 months (factorial repeat-measures ANOVA (F [degrees of freedom {df} = 2, 187] = 0.846; P = .436; partial η 2 = 0.009). Hemoglobin levels were significantly increased after supplementation in all 3 supplement groups. Increases were not significantly different between groups (factorial repeat-measures ANOVA (F [df = 2, 187] = 0.549; P = .591; partial η 2 = 0.006).

Equivalent effects were observed. After 6 months of supplementation, mean CD4 count was not significantly different between groups. Hemoglobin concentration was significantly increased in all 3 groups, but increase did not differ between groups.
Original languageEnglish
Article numberpiaa025
JournalJournal of the Pediatric Infectious Diseases Society
Publication statusPublished - 23 Mar 2020


  • HIV
  • Hemoglobin
  • CD4 count determination procedure
  • HIV seropositivity
  • Micronutrients
  • Nigeria
  • Recommended daily allowance
  • Hemoglobin measurement
  • Multivitamins
  • Aids
  • Pediatric


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