The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

H.R. Scott, D.C. McMillan, A. Crilly, C.S. McArdle, R. Milroy

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Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.

Original languageEnglish
Pages (from-to)1560-2
Number of pages3
JournalBritish Journal of Cancer
Issue number12
Publication statusPublished - Jun 1996
Externally publishedYes



  • Acute-Phase Reaction
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung
  • Female
  • Humans
  • Interleukin-6
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Weight Loss

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