The Red Sea marine sponge Spongia irregularis: metabolomic profiling and cytotoxic potential supported by in silico studies

Enas Reda Abdelaleem, Mamdouh Nabil Samy, Safwat A. Ahmed, Asmaa M. AboulMagd, Albaraa Hani Alhadrami, Mostafa E. Rateb, Usama Ramadan Abdelmohsen*, Samar Yehia Desoukey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The current study discusses the chemical composition of the marine sponge Spongia irregularis using LC-HRESIMS. The metabolomic profiling resulted in the annotation of 17 metabolites of different chemical classes. Additionally, evaluation of the cytotoxic activities of the total extract and different fractions were carried out against three different cell lines where the n-butanol fraction exhibited the highest cytotoxic effects against HepG-2, MCF-7 and CACO-2 cell lines with IC50 values of 9.6 ± 0.02, 4.3 ± 0.10 and 5.6 ± 0.03 µg/mL, respectively. Also, the study was supported by docking study of the identified compounds for binding affinity to MSK1.

Original languageEnglish
Number of pages5
JournalNatural Product Research
Early online date27 Jan 2022
DOIs
Publication statusE-pub ahead of print - 27 Jan 2022

Keywords

  • cytotoxic
  • LC-HRESIMS
  • metabolomics
  • sponges
  • Spongia irregularis

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