The impact of laboratory characteristics on molecular detection of respiratory syncytial virus in a European multicentre quality control study

T.J. Meerhoff; W.G. MacKay; A. Meijer; W.J. Paget; H.G.M. Niesters; J.L.L. Kimpen; F. Schellevis

doi:10.1111/j.1469-0691.2008.02100.x

The impact of laboratory characteristics on molecular detection of respiratory syncytial virus in a European multicentre quality control study

T.J. Meerhoff, W.G. MacKay, A. Meijer, W.J. Paget, H.G.M. Niesters, J.L.L. Kimpen, F. Schellevis

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Abstract

The performance of nucleic acid amplification techniques for detecting respiratory syncytial virus (RSV) was evaluated in 25 laboratories across Europe by an external quality assessment study. In addition, factors related to the diagnostic performance of laboratories were explored. The results of this quality control study show that the performance of laboratories for RSV diagnosis in Europe is good, with an overall correct score of 88%. The type of assay (nested or real-time PCR vs. commercial tests) was identified as a significant factor (OR 8.39; 95% CI 1.91?36.78) in predicting a correct result.

Original language	English
Pages (from-to)	1173-1176
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	14
Issue number	12
DOIs	https://doi.org/10.1111/j.1469-0691.2008.02100.x
Publication status	Published - Dec 2008
Externally published	Yes

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title = "The impact of laboratory characteristics on molecular detection of respiratory syncytial virus in a European multicentre quality control study",

abstract = "The performance of nucleic acid amplification techniques for detecting respiratory syncytial virus (RSV) was evaluated in 25 laboratories across Europe by an external quality assessment study. In addition, factors related to the diagnostic performance of laboratories were explored. The results of this quality control study show that the performance of laboratories for RSV diagnosis in Europe is good, with an overall correct score of 88%. The type of assay (nested or real-time PCR vs. commercial tests) was identified as a significant factor (OR 8.39; 95% CI 1.91?36.78) in predicting a correct result.",

author = "T.J. Meerhoff and W.G. MacKay and A. Meijer and W.J. Paget and H.G.M. Niesters and J.L.L. Kimpen and F. Schellevis",

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AU - Meerhoff, T.J.

AU - MacKay, W.G.

AU - Meijer, A.

AU - Paget, W.J.

AU - Niesters, H.G.M.

AU - Kimpen, J.L.L.

AU - Schellevis, F.

PY - 2008/12

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AB - The performance of nucleic acid amplification techniques for detecting respiratory syncytial virus (RSV) was evaluated in 25 laboratories across Europe by an external quality assessment study. In addition, factors related to the diagnostic performance of laboratories were explored. The results of this quality control study show that the performance of laboratories for RSV diagnosis in Europe is good, with an overall correct score of 88%. The type of assay (nested or real-time PCR vs. commercial tests) was identified as a significant factor (OR 8.39; 95% CI 1.91?36.78) in predicting a correct result.

U2 - 10.1111/j.1469-0691.2008.02100.x

DO - 10.1111/j.1469-0691.2008.02100.x

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EP - 1176

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 12

ER -

The impact of laboratory characteristics on molecular detection of respiratory syncytial virus in a European multicentre quality control study

Abstract

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