The growth hormone/insulin-like growth factor system in the management of diabetes and obesity

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is well recognised that the growth hormone (GH)/insulin-like growth factor (IGF) system is well recognised to have a role in diabetes and obesity. The IGFs (IGF-I and IGF-II) have structural similarity to proinsulin and the type 1 IGF receptors and insulin receptors are able to form heterodimers that participate in metabolic and mitogenic signalling. Obesity, diabetes and the metabolic syndrome are associated with alterations in the GH/IGF system. Perturbations in this system are also associated with predisposition to diabetes, obesity and the metabolic syndrome and also the risk of vascular and other complications.

Targeting this system holds therapeutic promise. Therefore, having introduced the relevant physiology and pathophysiology, the evidence base in to using GH and IGFs in the management of GH and IGFs therapy will be presented and the advantages and limitations of such approaches will be discussed.
Original languageEnglish
Title of host publicationFrontiers in Clinical Drug Research - Diabetes and Obesity
EditorsAtta ur-Rahman
PublisherBentham eBooks
Pages59-80
Number of pages22
Volume3
ISBN (Electronic)978-1-68108-247-9
ISBN (Print)978-1-68108-248-6
Publication statusPublished - 2016

Publication series

NameFrontiers in Clinical Drug Research – Diabetes and Obesity
PublisherBentham
Volume3
ISSN (Print)2467-9607
ISSN (Electronic)2352-3220

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  • Cite this

    Lewitt, M. (2016). The growth hormone/insulin-like growth factor system in the management of diabetes and obesity. In A. ur-Rahman (Ed.), Frontiers in Clinical Drug Research - Diabetes and Obesity (Vol. 3, pp. 59-80). (Frontiers in Clinical Drug Research – Diabetes and Obesity; Vol. 3). Bentham eBooks. https://ebooks.benthamscience.com/book/9781681082479/chapter/148157/