The genus Micromonospora as a model microorganism for bioactive natural product discovery

Mohamed S. Hifnawy; Mohamed M. Fouda; Ahmed M. Sayed; Rabab Mohammed; Hossam M. Hassan; Sameh F. AbouZid; Mostafa E. Rateb; Alexander Keller; Martina Adamek; Nadine Ziemert; Usama Ramadan Abdelmohsen

doi:10.1039/D0RA04025H

The genus Micromonospora as a model microorganism for bioactive natural product discovery

Mohamed S. Hifnawy, Mohamed M. Fouda, Ahmed M. Sayed, Rabab Mohammed, Hossam M. Hassan, Sameh F. AbouZid, Mostafa E. Rateb, Alexander Keller, Martina Adamek, Nadine Ziemert^*, Usama Ramadan Abdelmohsen

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.

Original language	English
Pages (from-to)	20939-20959
Number of pages	21
Journal	RSC Advances
Volume	10
Issue number	35
DOIs	https://doi.org/10.1039/D0RA04025H
Publication status	Published - 8 Jun 2020

Keywords

Micromonospora
genome mining
genetic engineering

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10.1039/D0RA04025HLicence: CC BY

2020 05 28 Hifnawy et al Micromonospora finalFinal published version, 2.61 MBLicence: CC BY
2020 05 28 Hifnawy et al Micromonospora supplementaryFinal published version, 649 KBLicence: CC BY

Cite this

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title = "The genus Micromonospora as a model microorganism for bioactive natural product discovery",

abstract = "This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.",

keywords = "Micromonospora, genome mining, genetic engineering",

author = "Hifnawy, {Mohamed S.} and Fouda, {Mohamed M.} and Sayed, {Ahmed M.} and Rabab Mohammed and Hassan, {Hossam M.} and AbouZid, {Sameh F.} and Rateb, {Mostafa E.} and Alexander Keller and Martina Adamek and Nadine Ziemert and Abdelmohsen, {Usama Ramadan}",

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month = jun,

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doi = "10.1039/D0RA04025H",

language = "English",

volume = "10",

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journal = "RSC Advances",

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AU - Hifnawy, Mohamed S.

AU - Fouda, Mohamed M.

AU - Sayed, Ahmed M.

AU - Mohammed, Rabab

AU - Hassan, Hossam M.

AU - AbouZid, Sameh F.

AU - Rateb, Mostafa E.

AU - Keller, Alexander

AU - Adamek, Martina

AU - Ziemert, Nadine

AU - Abdelmohsen, Usama Ramadan

PY - 2020/6/8

Y1 - 2020/6/8

N2 - This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.

AB - This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.

KW - Micromonospora

KW - genome mining

KW - genetic engineering

U2 - 10.1039/D0RA04025H

DO - 10.1039/D0RA04025H

M3 - Review article

SN - 2046-2069

VL - 10

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EP - 20959

JO - RSC Advances

JF - RSC Advances

IS - 35

ER -

The genus Micromonospora as a model microorganism for bioactive natural product discovery

Abstract

Keywords

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