The genus Micromonospora as a model microorganism for bioactive natural product discovery

Mohamed S. Hifnawy, Mohamed M. Fouda, Ahmed M. Sayed, Rabab Mohammed, Hossam M. Hassan, Sameh F. AbouZid, Mostafa E. Rateb, Alexander Keller, Martina Adamek, Nadine Ziemert*, Usama Ramadan Abdelmohsen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
29 Downloads (Pure)

Abstract

This review covers the development of the genus Micromonospora as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.
Original languageEnglish
Pages (from-to)20939-20959
Number of pages21
JournalRSC Advances
Volume10
DOIs
Publication statusPublished - 8 Jun 2020

Keywords

  • Micromonospora
  • genome mining
  • genetic engineering

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