The purpose of this study was to evaluate the efficacy of a specific 8-week exercise rehabilitation program as an intervention to treat recurrent nonspecific low back pain in adolescents. A randomized controlled trial involving 54 adolescents (14.6 ± 0.6 years) who suffered from recurrent nonspecific low back pain participated in either the exercise rehabilitation program or a control condition. Pre- and postintervention measures of low back pain status and biological risk indicators were taken. Two-way mixed ANOVA was conducted and significance was set at p < .01. Significant improvement was noted in the exercise rehabilitation group for perceived severity of pain (effect size 1.47) and number of occasions missing physical activity (effect size 0.99). Significant improvement in the exercise rehabilitation group for sit-and-reach performance, hip range of motion, lumbar sagittal mobility (modified Schöber), and number of sit-ups in 60 s were also identified. In conclusion, the specific exercise program appeared to provide positive benefits for adolescents suffering from recurrent nonspecific low back pain. Further evaluation is required to evaluate the effectiveness of the exercise rehabilitation program in relation to other interventions and to assess the long-term effectiveness.