The effects of non-therapeutic anabolic androgenic steroid (AAS) use on cardiac structure and function

Fergal M. Grace*, Nick Sculthorpe, Julien S. Baker, Lon Kilgore

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Studies investigating the effects of Anabolic Androgenic Steroids (AAS) on the cardiovascular system have been present in the medical literature over the past forty years. The present chapter reviews the available literature on the impact that AAS use has on cardiovascular structure and function from the more popular studies in the 1980s, investigating the effects of AAS on cholesterol levels to the more currently popular studies that aim to identify the underlying mechanisms behind remodeling of cardiac muscle. There is currently good progress being made in understanding the physiological mechanisms behind AAS induced cardio-toxicity from both the in vitro and animal model. If current rates of progress are continued and the medical research community continues to publish both controlled and case studies then a clearer understanding of the mechanisms behind cardiovascular problems resulting from AAS use are expected in the near future.

Original languageEnglish
Title of host publicationPerspectives on Anabolic Androgenic Steroids (AAS) and Doping in Sport and Health
EditorsFergal Grace
PublisherNova Science Publishers, Inc.
Number of pages25
ISBN (Electronic)9781620812617
ISBN (Print)9781620812433
Publication statusPublished - 31 Jul 2012

Publication series

NameSports and Athletics Preparation, Performance, and Psychology, Substance Abuse Assessment, Interventions and Treatment
PublisherNova Science Publishers, Inc.


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