Abstract
Branched-chain amino acids (BCAA) are used as nutritional support for patients with a range of conditions including liver cirrhosis and in-born errors of amino acid metabolism, and are commonly used “sports”/exercise supplements. The effects of the BCAA on the in-vitro activity of calf intestinal alkaline phosphatase (EC. 3.1.3.1) were studied. All three BCAA were found to be uncompetitive inhibitors of the enzyme with L-leucine being the most potent (Ki’ = 24.9mM) and L-valine, the least potent (Ki’ = 37mM). Mixed BCAA are able to act in combination to inhibit the enzyme. Given the important role of intestinal alkaline phosphatase in gut homeostasis, these findings have potential implications for those taking high levels of BCAA as supplements.
| Original language | English |
|---|---|
| Pages (from-to) | 632-636 |
| Number of pages | 5 |
| Journal | Applied Physiology, Nutrition, and Metabolism |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2019 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- intenstinal alkaline phosphatase
- branched-chain amino acids
- supplements
- L-leucine
- L-isoleucine
- L-valine
Fingerprint
Dive into the research topics of 'The effect of the branched-chain amino acids on the in-vitro activity of bovine intestinal alkaline phosphatase'. Together they form a unique fingerprint.Profiles
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver