The effect of exercise on glucoregulatory hormones: a countermeasure to human aging: insights from a comprehensive review of the literature

Nicola Luigi Bragazzi*, Maha Sellami, Maamer Slimani, Lawrence Hayes, Georges Jabbour, Andrea De Giorgio, Benoit Dugué

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)


Hormones are secreted in a circadian rhythm, but also follow larger-scale timetables, such as monthly (hormones of the menstrual cycle), seasonal (i.e., winter, summer), and, ultimately, lifespan-related patterns. Several contexts modulate their secretion, such as genetics, lifestyle, environment, diet, and exercise. They play significant roles in human physiology, influencing growth of muscle, bone, and regulating metabolism. Exercise training alters hormone secretion, depending on the frequency, duration, intensity, and mode of training which has an impact on the magnitude of the secretion. However, there remains ambiguity over the effects of exercise training on certain hormones such as glucoregulatory hormones in aging adults. With advancing age, there are many alterations with the endocrine system, which may ultimately alter human physiology. Some recent studies have reported an anti-aging effect of exercise training on the endocrine system and especially cortisol, growth hormone and insulin. As such, this review examines the effects of endurance, interval, resistance and combined training on hormones (i.e., at rest and after) exercise in older individuals. We summarize the influence of age on glucoregulatory hormones, the influence of exercise training, and where possible, examine masters’ athletes’ endocrinological profile.

Original languageEnglish
Article number1709
Number of pages17
JournalInternational Journal of Environmental Research and Public Health
Issue number10
Publication statusPublished - 15 May 2019
Externally publishedYes



  • Advanced age and senescence
  • Cortisol
  • Glucose
  • Growth hormone
  • Insulin
  • Physical activity

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