The dopamine D4 receptor gene (DRD4) is associated with attentional bias in heroin abusers and cigarette smokers

J. Lusher, C. Chandler, D. Ball

Research output: Contribution to journalArticle

Abstract

The search for a genetic vulnerability gene for substance abuse has focused on dopaminergic genes, including the DRD4 receptor. In addition to clear biological mechanisms in substance abuse, many studies have found a psychological attentional bias to drug-related stimuli in substance users. This study aimed to determine whether a DRD4 gene polymorphism is associated with such attentional biases to substance-related stimuli. Eighty heroin abusers in treatment, 80 cigarette smokers, 80 alcohol abusers in treatment and 80 non-smoking community controls undertook an emotional Stroop task to measure attentional bias to drug-related stimuli. DNA was obtained from cheek cell samples and the DRD4 VNTR polymorphism genotyped. Heroin abusers and cigarette smokers, but not controls, who carried the long variant at the DRD4 gene spent significantly longer responding to drug-related stimuli than they did to neutral stimuli when compared to those who did not carry the long variant at the DRD4 gene. A non-significant trend to delay was observed in alcoholics. These findings suggest that variants at the DRD4 gene influence attentional bias in substance abusers and offer further insight into the role of the DRD4 gene in drug dependence as well as individual differences in the susceptibility to attentional bias to drug-related environmental cues.
Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalOpen Addiction Journal
Volume2
Issue number6
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Dopamine D4 Receptors
Heroin
Tobacco Products
Genes
Substance-Related Disorders
Pharmaceutical Preparations
Cheek
Alcoholics
Attentional Bias
Individuality
Cues
Alcohols
Psychology
DNA
Therapeutics

Cite this

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abstract = "The search for a genetic vulnerability gene for substance abuse has focused on dopaminergic genes, including the DRD4 receptor. In addition to clear biological mechanisms in substance abuse, many studies have found a psychological attentional bias to drug-related stimuli in substance users. This study aimed to determine whether a DRD4 gene polymorphism is associated with such attentional biases to substance-related stimuli. Eighty heroin abusers in treatment, 80 cigarette smokers, 80 alcohol abusers in treatment and 80 non-smoking community controls undertook an emotional Stroop task to measure attentional bias to drug-related stimuli. DNA was obtained from cheek cell samples and the DRD4 VNTR polymorphism genotyped. Heroin abusers and cigarette smokers, but not controls, who carried the long variant at the DRD4 gene spent significantly longer responding to drug-related stimuli than they did to neutral stimuli when compared to those who did not carry the long variant at the DRD4 gene. A non-significant trend to delay was observed in alcoholics. These findings suggest that variants at the DRD4 gene influence attentional bias in substance abusers and offer further insight into the role of the DRD4 gene in drug dependence as well as individual differences in the susceptibility to attentional bias to drug-related environmental cues.",
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The dopamine D4 receptor gene (DRD4) is associated with attentional bias in heroin abusers and cigarette smokers. / Lusher, J.; Chandler, C.; Ball, D.

In: Open Addiction Journal, Vol. 2, No. 6, 2009, p. 6-11.

Research output: Contribution to journalArticle

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