The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults

Hannah Margaret Lithgow, Geraint Florida-James, Melanie Leggate*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
22 Downloads (Pure)

Abstract

High-intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ± 9 year; BMI, 31.4 ± 2.8 kg·m−2) completed 6 weeks HIIT, and were randomized to ingest 100 μg·day -1 of vitamin D3 or placebo. Response to an oral glucose tolerance test (OGTT) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT, accompanied by a decrease in glucose (829 ± 110 to 786 ± 139 mmol·h−1·L−1; P = 0.043) and insulin (8101 ± 4755–7024 ± 4489 mU·h−1·L−1; P = 0.049) area under the curve (AUC). Supplementation increased 25-hydroxyvitamin D3 concentration by 120% to a sufficiency status (P < 0.001). However, the consumption of vitamin D3 seemed to attenuate the glucose response during an OGTT. Triglyceride content was lowered following the intervention (P = 0.025). There was no effect of the intervention on insulin sensitivity (IS) indices: ISIMatsuda and HOMA-IR. Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D3 supplementation did not proffer any additional positive effects on the measured indices of metabolic health.

Original languageEnglish
Article numbere13684
Number of pages12
JournalPhysiological Reports
Volume6
Issue number9
DOIs
Publication statusPublished - 30 Apr 2018
Externally publishedYes

Keywords

  • Glucose tolerance
  • High-intensity intermittent training
  • Vitamin D

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