The clinical importance of fungal biofilms

Gordon Ramage, Craig Williams

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Fungal biofilms have become an increasingly important clinical problem. The widespread use of antibiotics, frequent use of indwelling medical devices, and a trend toward increased patient immunosuppression have resulted in a creation of opportunity for clinically important yeasts and molds to form biofilms. This review will discuss the diversity and importance of fungal biofilms in the context of clinical medicine, provide novel insights into the clinical management of fungal biofilm infection, present evidence why these structures are recalcitrant to antifungal therapy, and discuss how our knowledge and understanding may lead to novel therapeutic intervention.

Original languageEnglish
Pages (from-to)27-83
Number of pages57
JournalAdvances in Applied Microbiology
Volume84
Early online date5 Jun 2013
DOIs
Publication statusPublished - 2013

Keywords

  • Biofilms
  • Drug Resistance, Fungal
  • Fungi
  • Humans
  • Mycoses

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