TY - JOUR
T1 - The anti-adhesive effect of curcumin on Candida albicans biofilms on denture materials
AU - Alalwan, Hasanain K.A.
AU - Rajendran, Ranjith
AU - Lappin, David F.
AU - Combet, Emilie
AU - Shahzad, Muhammad
AU - Robertson, Douglas
AU - Nile, Christopher J.
AU - Williams, Craig
AU - Ramage, Gordon
PY - 2017/4/20
Y1 - 2017/4/20
N2 - The use of natural compounds as an alternative source of antimicrobials has become a necessity given the growing concern over global antimicrobial resistance. Polyphenols, found in various edible plants, offers one potential solution to this. We aimed to investigate the possibility of using curcumin within the context of oral health as a way of inhibiting and preventing the harmful development of Candida albicans biofilms. We undertook a series of adsorption experiments with varying concentrations of curcumin, showing that 50 ug/ml could prevent adhesion. This effect could be further synergised by the curcumin pretreatment of yeast cells to obtain significantly greater inhibition (>90%, p
AB - The use of natural compounds as an alternative source of antimicrobials has become a necessity given the growing concern over global antimicrobial resistance. Polyphenols, found in various edible plants, offers one potential solution to this. We aimed to investigate the possibility of using curcumin within the context of oral health as a way of inhibiting and preventing the harmful development of Candida albicans biofilms. We undertook a series of adsorption experiments with varying concentrations of curcumin, showing that 50 ug/ml could prevent adhesion. This effect could be further synergised by the curcumin pretreatment of yeast cells to obtain significantly greater inhibition (>90%, p
U2 - 10.3389/fmicb.2017.00659
DO - 10.3389/fmicb.2017.00659
M3 - Article
SN - 1664-302X
VL - 8
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
ER -