The anti-adhesive effect of curcumin on Candida albicans biofilms on denture materials

Hasanain K.A. Alalwan, Ranjith Rajendran, David F. Lappin, Emilie Combet, Muhammad Shahzad, Douglas Robertson, Christopher J. Nile, Craig Williams, Gordon Ramage

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The use of natural compounds as an alternative source of antimicrobials has become a necessity given the growing concern over global antimicrobial resistance. Polyphenols, found in various edible plants, offers one potential solution to this. We aimed to investigate the possibility of using curcumin within the context of oral health as a way of inhibiting and preventing the harmful development of Candida albicans biofilms. We undertook a series of adsorption experiments with varying concentrations of curcumin, showing that 50 ug/ml could prevent adhesion. This effect could be further synergised by the curcumin pretreatment of yeast cells to obtain significantly greater inhibition (>90%, p
Original languageEnglish
JournalFrontiers in Microbiology
Volume8
DOIs
Publication statusPublished - 20 Apr 2017

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