Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe

Randa Abdou; Samah Shabana; Mostafa E. Rateb

doi:10.1080/14786419.2018.1489393

Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe

Randa Abdou, Samah Shabana, Mostafa E. Rateb^*

^*Corresponding author for this work

School of Computing, Engineering and Physical Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

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Abstract

Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.

Original language	English
Pages (from-to)	503-510
Number of pages	8
Journal	Natural Product Research
Volume	34
Issue number	4
Early online date	9 Aug 2018
DOIs	https://doi.org/10.1080/14786419.2018.1489393
Publication status	E-pub ahead of print - 9 Aug 2018

Keywords

Terezine E
endophyte
cytotoxic
Antimicrobial

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10.1080/14786419.2018.1489393

2018 06 12 Abdou Terezine EAccepted author manuscript, 144 KBLicence: CC BY-NC-ND

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AU - Shabana, Samah

AU - Rateb, Mostafa E.

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AB - Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.

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KW - endophyte

KW - cytotoxic

KW - Antimicrobial

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ER -

Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe

Abstract

Keywords

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