Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe

Randa Abdou, Samah Shabana, Mostafa E. Rateb*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
208 Downloads (Pure)

Abstract

Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalNatural Product Research
Volume34
Issue number4
Early online date9 Aug 2018
DOIs
Publication statusE-pub ahead of print - 9 Aug 2018

Keywords

  • Terezine E
  • endophyte
  • cytotoxic
  • Antimicrobial

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