Abstract
The leukemic oncogene Tel/PDGFR beta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFR beta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFR beta-expressing cells. This study indicates Tel/PDGFR beta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 1554-1564 |
| Number of pages | 11 |
| Journal | Leukemia Research |
| Volume | 32 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2008 |
| Externally published | Yes |
Keywords
- leukemia
- tyrosine kinase
- Tel/PDGFR beta
- embryonic stem cell
- gene expression
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