Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells

E. Dobbin, P. M. Corrigan, C. P. Walsh, M. J. Welham, R. W. Freeburn, H. Wheadon

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The leukemic oncogene Tel/PDGFR beta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFR beta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFR beta-expressing cells. This study indicates Tel/PDGFR beta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.
Original languageEnglish
Pages (from-to)1554-1564
Number of pages11
JournalLeukemia Research
Issue number10
Publication statusPublished - Oct 2008
Externally publishedYes


  • leukemia
  • tyrosine kinase
  • Tel/PDGFR beta
  • embryonic stem cell
  • gene expression


Dive into the research topics of 'Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells'. Together they form a unique fingerprint.

Cite this