Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent

Gary J. Litherland, Craig Dixon, Rachel L. Lakey, Timothy Robson, Debra Jones, David A. Young, Tim E. Cawston, Andrew D. Rowan

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

48 Citations
10 Article
3 Meeting Abstract

13 results

2018
Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes
Baker, J., Falconer, A., Wilkinson, D. J., Europe-Finner, G. N., Litherland, G. & Rowan, A. D., 13 Apr 2018, In: PLoS ONE. 13, 4, 19 p., e0195864.
Research output: Contribution to journal › Article › peer-review

Open Access
21 Citations (Scopus)
2017
Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation
Chan, C. M., Macdonald, C. D., Litherland, G., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N. & Rowan, A. D., 3 Feb 2017, In: Journal of Biological Chemistry. 292, 5, p. 1625-1636 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
46 Citations (Scopus)
2015
Tribbles and arthritis: what are the links?
Rowan, A. D. & Litherland, G. J., Oct 2015, In: Biochemical Society Transactions. 43, p. 1051-1056
Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
2014
Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis
Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., Young, D. A. & Rowan, A. D., Aug 2014, In: Arthritis & Rheumatology. 66, 8, p. 2175-2187 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
19 Citations (Scopus)
2013

The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes
Baker, J., Litherland, G. J. & Rowan, A. D., Apr 2013, In: Rheumatology. 52, S1, p. S49-S49 1 p.
Research output: Contribution to journal › Meeting Abstract › peer-review
2012

Glycogen synthase kinase-3 as a gatekeeper of human cartilage degradation
Litherland, G. J., Elias, M. S., Curtis, H. & Rowan, A. D., 1 Aug 2012, In: International Journal of Experimental Pathology. 93, 4, p. A31-A31
Research output: Contribution to journal › Meeting Abstract › peer-review
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases
Hui, W., Litherland, G. J., Elias, M. S., Kitson, G. I., Cawston, T. E., Rowan, A. D. & Young, D. A., Mar 2012, In: Annals of the Rheumatic Diseases. 71, 3, p. 455-62 8 p.
Research output: Contribution to journal › Article › peer-review
170 Citations (Scopus)
2010
HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes
Barter, M. J., Pybus, L., Litherland, G. J., Rowan, A. D., Clark, I. M., Edwards, D. R., Cawston, T. E. & Young, D. A., Sept 2010, In: Matrix Biology. 29, 7, p. 602-612
Research output: Contribution to journal › Article › peer-review
72 Citations (Scopus)
Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway
Hui, W., Litherland, G. J., Jefferson, M., Barter, M. J., Elias, M. S., Cawston, T. E., Rowan, A. D. & Young, D. A., Nov 2010, In: Rheumatology. 49, 11, p. 2043-2053
Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus)
Protein Kinase C Isoforms zeta and iota Mediate Collagenase Expression and Cartilage Destruction via STAT3-and ERK-dependent c-fos Induction
Litherland, G. J., Elias, M. S., Hui, W., Macdonald, C. D., Catterall, J. B., Barter, M. J., Farren, M. J., Jefferson, M. & Rowan, A. D., 16 Jul 2010, In: Journal of Biological Chemistry. 285, 29, p. 22414-22425
Research output: Contribution to journal › Article › peer-review

Open Access
46 Citations (Scopus)
2009

Role of protein kinase C isoforms in collagenase induction and cartilage degradation
Rowan, A. D. & Litherland, G., 2009, In: Osteoarthritis and Cartilage. 17, Supplement 1, p. S146
Research output: Contribution to journal › Meeting Abstract

Open Access
2008
Differential Toll-like receptor-dependent collagenase expression in chondrocytes
Zhang, Q., Hui, W., Litherland, G. J., Barter, M. J., Davidson, R., Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. & Young, D. A., Nov 2008, In: Annals of the Rheumatic Diseases. 67, 11, p. 1633-1641
Research output: Contribution to journal › Article › peer-review
83 Citations (Scopus)
Metalloproteases as potential therapeutic targets in arthritis treatment
Rowan, A. D., Litherland, G. J., Hui, W. & Milner, J. M., Jan 2008, In: Expert Opinion on Therapeutic Targets. 12, 1, p. 1-18 18 p.
Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus)

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent

Research output

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