Superior skin microvascular vasodilator function in trained versus untrained male adolescents

Denise Roche, Thomas Rowland, Max Garrard, Simon Marwood, Viswanath B. Unnithan

Research output: Contribution to journalMeeting Abstract

Abstract

In youth, remedial benefits of exercise training on conduit vessel endothelium-dependent vasodilator function have recently been documented, however it remains to be established whether exercise training also impacts on endothelium-dependent vasodilator function at the microvascular level in youth who are free from chronic disease.

PURPOSE: To determine whether a group of trained youth have superior skin microvascular endothelium-dependent vasodilator function compared to untrained healthy controls.

METHODS: Forearm skin blood flow (SkBF) was assessed in 17 trained (14.6 ± 0.2 yrs, VO2peak: 54.9 ± 1.5 mL.kg-1.min-1, Self-assessed Tanner stage 2 - 4) and 9 untrained (15.6 ± 0.2 yrs, VO2peak: 43.1 ± 1.7 mL.kg-1.min-1, Tanner stage 2 - 4) male adolescents using laser Doppler flowmetry at baseline (basal SkBF) and following physiological provocation. Endothelium-dependent vasodilator function of the skin microcirculation was assessed physiologically through local heating to 44°C for 30 minutes (maximal SkBF) and post-occlusive reactive hyperaemia (PORH), which involved SkBF assessment following 3 minutes of arterial occlusion. Cutaneous vascular conductance (CVC) (SkBF/MAP) was calculated at baseline and at maximal thermal flux.

RESULTS: Maximal SkBF was significantly higher in trained versus untrained youth (Trained: 281.7 ± 29.2 vs Untrained: 204.2 ± 22.6 PU, p=0.04). Maximal flux during PORH was also significantly higher in trained compared to untrained youth (Trained: 50.4 ± 5.2 vs Untrained: 35.2 ± 5.0 PU, p=0.04). Trained youth also demonstrated significantly greater basal SkBF and basal CVC (basal SkBF Trained: 11.2 ± 0.9 vs Untrained: 8.6 ± 1.0 PU, p=0.03; basal CVC Trained: 0.12 ± 0.01 vs Untrained 0.08 ± 0.01 PU/mmHg, p=0.04) and possessed superior maximal CVC (Trained: 3.00 ± 0.34 vs 2.02 ± 0.23 PU/mmHg, p=0.03) compared to their untrained counterparts.

CONCLUSION: Skin microvascular endothelium-dependent vasodilator function is significantly enhanced in healthy, trained male adolescents. This may have implications for the prevention of endothelial dysfunction with aging and chronic diseases such as diabetes.
Original languageEnglish
Pages (from-to)64-64
Number of pages1
JournalMedicine & Science in Sports & Exercise
Volume41
Issue number5
DOIs
Publication statusPublished - May 2009
Externally publishedYes

Fingerprint

Vasodilator Agents
Skin
Endothelium-Dependent Relaxing Factors
Blood Vessels
Hyperemia
Chronic Disease
Exercise
Exercise Therapy
Laser-Doppler Flowmetry
Microcirculation
Forearm
Heating
Hot Temperature

Cite this

Roche, Denise ; Rowland, Thomas ; Garrard, Max ; Marwood, Simon ; Unnithan, Viswanath B. / Superior skin microvascular vasodilator function in trained versus untrained male adolescents. In: Medicine & Science in Sports & Exercise. 2009 ; Vol. 41, No. 5. pp. 64-64.
@article{e5b28443c8074902b6bed58b3d70782f,
title = "Superior skin microvascular vasodilator function in trained versus untrained male adolescents",
abstract = "In youth, remedial benefits of exercise training on conduit vessel endothelium-dependent vasodilator function have recently been documented, however it remains to be established whether exercise training also impacts on endothelium-dependent vasodilator function at the microvascular level in youth who are free from chronic disease.PURPOSE: To determine whether a group of trained youth have superior skin microvascular endothelium-dependent vasodilator function compared to untrained healthy controls.METHODS: Forearm skin blood flow (SkBF) was assessed in 17 trained (14.6 ± 0.2 yrs, VO2peak: 54.9 ± 1.5 mL.kg-1.min-1, Self-assessed Tanner stage 2 - 4) and 9 untrained (15.6 ± 0.2 yrs, VO2peak: 43.1 ± 1.7 mL.kg-1.min-1, Tanner stage 2 - 4) male adolescents using laser Doppler flowmetry at baseline (basal SkBF) and following physiological provocation. Endothelium-dependent vasodilator function of the skin microcirculation was assessed physiologically through local heating to 44°C for 30 minutes (maximal SkBF) and post-occlusive reactive hyperaemia (PORH), which involved SkBF assessment following 3 minutes of arterial occlusion. Cutaneous vascular conductance (CVC) (SkBF/MAP) was calculated at baseline and at maximal thermal flux.RESULTS: Maximal SkBF was significantly higher in trained versus untrained youth (Trained: 281.7 ± 29.2 vs Untrained: 204.2 ± 22.6 PU, p=0.04). Maximal flux during PORH was also significantly higher in trained compared to untrained youth (Trained: 50.4 ± 5.2 vs Untrained: 35.2 ± 5.0 PU, p=0.04). Trained youth also demonstrated significantly greater basal SkBF and basal CVC (basal SkBF Trained: 11.2 ± 0.9 vs Untrained: 8.6 ± 1.0 PU, p=0.03; basal CVC Trained: 0.12 ± 0.01 vs Untrained 0.08 ± 0.01 PU/mmHg, p=0.04) and possessed superior maximal CVC (Trained: 3.00 ± 0.34 vs 2.02 ± 0.23 PU/mmHg, p=0.03) compared to their untrained counterparts.CONCLUSION: Skin microvascular endothelium-dependent vasodilator function is significantly enhanced in healthy, trained male adolescents. This may have implications for the prevention of endothelial dysfunction with aging and chronic diseases such as diabetes.",
author = "Denise Roche and Thomas Rowland and Max Garrard and Simon Marwood and Unnithan, {Viswanath B.}",
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doi = "10.1249/01.MSS.0000354757.09939.2e",
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}

Superior skin microvascular vasodilator function in trained versus untrained male adolescents. / Roche, Denise; Rowland, Thomas; Garrard, Max; Marwood, Simon; Unnithan, Viswanath B.

In: Medicine & Science in Sports & Exercise, Vol. 41, No. 5, 05.2009, p. 64-64.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Superior skin microvascular vasodilator function in trained versus untrained male adolescents

AU - Roche, Denise

AU - Rowland, Thomas

AU - Garrard, Max

AU - Marwood, Simon

AU - Unnithan, Viswanath B.

PY - 2009/5

Y1 - 2009/5

N2 - In youth, remedial benefits of exercise training on conduit vessel endothelium-dependent vasodilator function have recently been documented, however it remains to be established whether exercise training also impacts on endothelium-dependent vasodilator function at the microvascular level in youth who are free from chronic disease.PURPOSE: To determine whether a group of trained youth have superior skin microvascular endothelium-dependent vasodilator function compared to untrained healthy controls.METHODS: Forearm skin blood flow (SkBF) was assessed in 17 trained (14.6 ± 0.2 yrs, VO2peak: 54.9 ± 1.5 mL.kg-1.min-1, Self-assessed Tanner stage 2 - 4) and 9 untrained (15.6 ± 0.2 yrs, VO2peak: 43.1 ± 1.7 mL.kg-1.min-1, Tanner stage 2 - 4) male adolescents using laser Doppler flowmetry at baseline (basal SkBF) and following physiological provocation. Endothelium-dependent vasodilator function of the skin microcirculation was assessed physiologically through local heating to 44°C for 30 minutes (maximal SkBF) and post-occlusive reactive hyperaemia (PORH), which involved SkBF assessment following 3 minutes of arterial occlusion. Cutaneous vascular conductance (CVC) (SkBF/MAP) was calculated at baseline and at maximal thermal flux.RESULTS: Maximal SkBF was significantly higher in trained versus untrained youth (Trained: 281.7 ± 29.2 vs Untrained: 204.2 ± 22.6 PU, p=0.04). Maximal flux during PORH was also significantly higher in trained compared to untrained youth (Trained: 50.4 ± 5.2 vs Untrained: 35.2 ± 5.0 PU, p=0.04). Trained youth also demonstrated significantly greater basal SkBF and basal CVC (basal SkBF Trained: 11.2 ± 0.9 vs Untrained: 8.6 ± 1.0 PU, p=0.03; basal CVC Trained: 0.12 ± 0.01 vs Untrained 0.08 ± 0.01 PU/mmHg, p=0.04) and possessed superior maximal CVC (Trained: 3.00 ± 0.34 vs 2.02 ± 0.23 PU/mmHg, p=0.03) compared to their untrained counterparts.CONCLUSION: Skin microvascular endothelium-dependent vasodilator function is significantly enhanced in healthy, trained male adolescents. This may have implications for the prevention of endothelial dysfunction with aging and chronic diseases such as diabetes.

AB - In youth, remedial benefits of exercise training on conduit vessel endothelium-dependent vasodilator function have recently been documented, however it remains to be established whether exercise training also impacts on endothelium-dependent vasodilator function at the microvascular level in youth who are free from chronic disease.PURPOSE: To determine whether a group of trained youth have superior skin microvascular endothelium-dependent vasodilator function compared to untrained healthy controls.METHODS: Forearm skin blood flow (SkBF) was assessed in 17 trained (14.6 ± 0.2 yrs, VO2peak: 54.9 ± 1.5 mL.kg-1.min-1, Self-assessed Tanner stage 2 - 4) and 9 untrained (15.6 ± 0.2 yrs, VO2peak: 43.1 ± 1.7 mL.kg-1.min-1, Tanner stage 2 - 4) male adolescents using laser Doppler flowmetry at baseline (basal SkBF) and following physiological provocation. Endothelium-dependent vasodilator function of the skin microcirculation was assessed physiologically through local heating to 44°C for 30 minutes (maximal SkBF) and post-occlusive reactive hyperaemia (PORH), which involved SkBF assessment following 3 minutes of arterial occlusion. Cutaneous vascular conductance (CVC) (SkBF/MAP) was calculated at baseline and at maximal thermal flux.RESULTS: Maximal SkBF was significantly higher in trained versus untrained youth (Trained: 281.7 ± 29.2 vs Untrained: 204.2 ± 22.6 PU, p=0.04). Maximal flux during PORH was also significantly higher in trained compared to untrained youth (Trained: 50.4 ± 5.2 vs Untrained: 35.2 ± 5.0 PU, p=0.04). Trained youth also demonstrated significantly greater basal SkBF and basal CVC (basal SkBF Trained: 11.2 ± 0.9 vs Untrained: 8.6 ± 1.0 PU, p=0.03; basal CVC Trained: 0.12 ± 0.01 vs Untrained 0.08 ± 0.01 PU/mmHg, p=0.04) and possessed superior maximal CVC (Trained: 3.00 ± 0.34 vs 2.02 ± 0.23 PU/mmHg, p=0.03) compared to their untrained counterparts.CONCLUSION: Skin microvascular endothelium-dependent vasodilator function is significantly enhanced in healthy, trained male adolescents. This may have implications for the prevention of endothelial dysfunction with aging and chronic diseases such as diabetes.

U2 - 10.1249/01.MSS.0000354757.09939.2e

DO - 10.1249/01.MSS.0000354757.09939.2e

M3 - Meeting Abstract

VL - 41

SP - 64

EP - 64

JO - Medicine & Science in Sports & Exercise

JF - Medicine & Science in Sports & Exercise

SN - 0195-9131

IS - 5

ER -