Six weeks of conditioning exercise increases total, but not free testosterone in lifelong sedentary aging men

Lawrence D. Hayes, Nicholas Sculthorpe, Peter Herbert, Julien S. Baker, Roberto Spagna, Fergal M. Grace

Research output: Contribution to journalArticle

Abstract

IntroductionAdvancing age is associated with a gradual decline in circulating androgens, and the putative role of exercise training on systemic androgens remains to be adequately defined. 
MethodsThe present investigation examined the impact of 6 weeks of supervised exercise training on resting levels of systemic hormones in a cohort of lifelong sedentary men [ SED ( n = 28), 62.5 +/- 5.3 years], compared with a positive control group of age- matched lifelong exercisers [ LE ( n = 20), 60.4 +/- 4.7 years, 430 years training history]. Blood hormones were sampled pre- and post- intervention from an antecubital forearm vein and analysed using electrochemiluminescent immunoassay. Cardiorespiratory fitness (VO2peak) was determined via indirect calorimetry during an incremental cycle test to volitional exhaustion. 
ResultsAnalysis of variance ( ANOVA) revealed a lack of significant change in any parameter amongst LE, whilst SED experienced a significant exercise- induced improvement in cardiorespiratory fitness and total testosterone ( all p<0.05). Concurrent increases in sex hormonebinding globulin ( SHBG; p<0.05) resulted in a lack of change to either bioavailable or calculated free testosterone ( p>0.05) amongst SED. 
ConclusionsAlthough resting levels of systemic total testosterone increased in response to 6 weeks of exercise training, increases in SHBG negated any potential relationship between calculated- free or bioavailable testosterone. These findings indicate that increases in bioavailable testosterone fraction are not required for cardiorespiratory fitness improvements in aging men.
Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalThe Aging Male
Volume18
Issue number3
DOIs
Publication statusPublished - 3 Jul 2015

Keywords

  • Aging
  • exercise
  • sex hormone-binding globulin
  • testosterone

Cite this

Hayes, Lawrence D. ; Sculthorpe, Nicholas ; Herbert, Peter ; Baker, Julien S. ; Spagna, Roberto ; Grace, Fergal M. / Six weeks of conditioning exercise increases total, but not free testosterone in lifelong sedentary aging men. In: The Aging Male. 2015 ; Vol. 18, No. 3. pp. 195-200.
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Six weeks of conditioning exercise increases total, but not free testosterone in lifelong sedentary aging men. / Hayes, Lawrence D.; Sculthorpe, Nicholas; Herbert, Peter; Baker, Julien S.; Spagna, Roberto; Grace, Fergal M.

In: The Aging Male, Vol. 18, No. 3, 03.07.2015, p. 195-200.

Research output: Contribution to journalArticle

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