Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction

M.R. Graham, Yaodong Gu, P.J. Evans, S.M. Cooper, B. Davies, Julien Baker

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Abstract

Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. 
Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. 
Results: PIIINP (0.28±0.1 vs. 0.42±0.2, U/ml); Insulin like growth factor-I (159±54 vs. 323±93, ng.mL-1); resting HR (72±14 vs. 78±11, b.p.m.) and rate pressure product (RPP) (90±18 vs. 97±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7±0.9 vs. 4.4±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77±2.1 vs. 1.29±1.6, mg.L-1); serum homocysteine (13.2±4.0 vs. 11.7±3.1, μmol.L-1) and APWV (9.97±1.38 vs. 9.18±1.6, m.s-1) all significantly decreased (P<0.05). 
Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.
Original languageEnglish
Pages (from-to)164-173
JournalInternational Journal of Advanced Engineering Research and Science
Volume4
Issue number7
DOIs
Publication statusPublished - Jul 2017

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Human Growth Hormone
Growth Hormone
Biomarkers
Pulse Wave Analysis
Cardiovascular Diseases
Heart Rate
Myocardial Infarction
Hypertension
Pressure
Collagen Type III
Aortic Aneurysm
Homocysteine
Insulin-Like Growth Factor I
Left Ventricular Function
C-Reactive Protein
Endothelium
Aneurysm
procollagen Type III-N-terminal peptide
Cholesterol
Blood Pressure

Cite this

Graham, M.R. ; Gu, Yaodong ; Evans, P.J. ; Cooper, S.M. ; Davies, B. ; Baker, Julien. / Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction. In: International Journal of Advanced Engineering Research and Science. 2017 ; Vol. 4, No. 7. pp. 164-173.
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abstract = "Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean {\^A}± SD, age 32 {\^A}± 11 years; height 1.8 {\^A}± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean {\^A}± SD, age 32 {\^A}± 9 years; height 1.8 {\^A}± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28{\^A}±0.1 vs. 0.42{\^A}±0.2, U/ml); Insulin like growth factor-I (159{\^A}±54 vs. 323{\^A}±93, ng.mL-1); resting HR (72{\^A}±14 vs. 78{\^A}±11, b.p.m.) and rate pressure product (RPP) (90{\^A}±18 vs. 97{\^A}±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7{\^A}±0.9 vs. 4.4{\^A}±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77{\^A}±2.1 vs. 1.29{\^A}±1.6, mg.L-1); serum homocysteine (13.2{\^A}±4.0 vs. 11.7{\^A}±3.1, {\^I}¼mol.L-1) and APWV (9.97{\^A}±1.38 vs. 9.18{\^A}±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.",
author = "M.R. Graham and Yaodong Gu and P.J. Evans and S.M. Cooper and B. Davies and Julien Baker",
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Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction. / Graham, M.R.; Gu, Yaodong; Evans, P.J. ; Cooper, S.M. ; Davies, B.; Baker, Julien.

In: International Journal of Advanced Engineering Research and Science, Vol. 4, No. 7, 07.2017, p. 164-173.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction

AU - Graham, M.R.

AU - Gu, Yaodong

AU - Evans, P.J.

AU - Cooper, S.M.

AU - Davies, B.

AU - Baker, Julien

PY - 2017/7

Y1 - 2017/7

N2 - Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28±0.1 vs. 0.42±0.2, U/ml); Insulin like growth factor-I (159±54 vs. 323±93, ng.mL-1); resting HR (72±14 vs. 78±11, b.p.m.) and rate pressure product (RPP) (90±18 vs. 97±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7±0.9 vs. 4.4±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77±2.1 vs. 1.29±1.6, mg.L-1); serum homocysteine (13.2±4.0 vs. 11.7±3.1, μmol.L-1) and APWV (9.97±1.38 vs. 9.18±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.

AB - Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28±0.1 vs. 0.42±0.2, U/ml); Insulin like growth factor-I (159±54 vs. 323±93, ng.mL-1); resting HR (72±14 vs. 78±11, b.p.m.) and rate pressure product (RPP) (90±18 vs. 97±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7±0.9 vs. 4.4±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77±2.1 vs. 1.29±1.6, mg.L-1); serum homocysteine (13.2±4.0 vs. 11.7±3.1, μmol.L-1) and APWV (9.97±1.38 vs. 9.18±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.

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DO - 10.22161/ijaers.4.7.26

M3 - Article

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JO - International Journal of Advanced Engineering Research and Science

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SN - 2349-6495

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ER -