Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics

David J. Wilkinson, Maria del Carmen Arques, Carmen Huesa, Andrew D. Rowan

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer and arthritis failed clinically, primarily due to poor selectivity for target MMPs. In recent years, roles for serine proteinases in the proteolytic cascades leading to cartilage destruction have become increasingly apparent, renewing interest in the potential for new therapeutic strategies that utilize pharmacological inhibitors against this class of proteinases. Herein, we describe key serine proteinases with likely importance in arthritic disease and highlight recent advances in this field.
Original languageEnglish
Pages (from-to)38-51
Number of pages14
JournalBritish Journal of Pharmacology
Volume176
Issue number1
Early online date23 Feb 2018
DOIs
Publication statusPublished - 31 Jan 2019

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