Sensitivity to change of aerobic exercise parameters in children with juvenile myositis

Tim Takken, Janjaap van der Net, Viswanath Unnithan, Jeroen A. Jeneson, Jihaan Hassan, Suzanne Pater, Raoul H. Engelbert, Paul J. Helders

Research output: Contribution to journalMeeting Abstract

Abstract

Juvenile myositis (JM) is a rare disease in which the immune system targets the microvasculature of the skeletal muscle and skin, leading to significant muscle weakness and exercise intolerance. 
PURPOSE: To investigate the changes in aerobic exercise parameters in children with JM during an active and inactive disease (remission) period, and secondly to study the sensitivity to change of these exercise parameters.
METHODS: 13 children with JM (mean±SD age: 11.2±2.6 years) participated in this study. Subjects performed a maximal exercise test using an electronically braked cycle ergometer and a calibrated respiratory gas analysis system (Jaeger Oxycon Pro). Exercise parameters that were measured and derived included: peak oxygen uptake (VO2peak), peak work rate (Wpeak), peak heart rate (HRpeak), and ventilatory anaerobic threshold (VAT). All children were tested during an active period of the disease as well as during a remission period. From these data four different responsiveness statistics were calculated: standardized response mean (SRM), Cohen's effect size (ES), paired t-tests and % change from baseline.
RESULTS: The children performed significantly better during the remission period compared to a period of active disease (see Table 1). Most exercise parameters showed a very large responsiveness (ES > 0.8)
CONCLUSION: We found that children with JM during the active disease phase had significantly reduced exercise parameters compared to a remission period. The physiological variables were not as sensitive to change compared to work rate. This suggests some type of metabolic disconnection, which might be caused by the reduced blood flow to the active musculature.
Original languageEnglish
Pages (from-to)S461-S461
Number of pages1
JournalMedicine & Science in Sports & Exercise
Volume40
Issue number5
DOIs
Publication statusPublished - May 2008
Externally publishedYes

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Exercise
Anaerobic Threshold
Muscle Weakness
Rare Diseases
Microvessels
Exercise Test
Juvenile dermatomyositis
Immune System
Skeletal Muscle
Heart Rate
Gases
Oxygen
Skin

Cite this

Takken, Tim ; van der Net, Janjaap ; Unnithan, Viswanath ; Jeneson, Jeroen A. ; Hassan, Jihaan ; Pater, Suzanne ; Engelbert, Raoul H. ; Helders, Paul J. / Sensitivity to change of aerobic exercise parameters in children with juvenile myositis. In: Medicine & Science in Sports & Exercise. 2008 ; Vol. 40, No. 5. pp. S461-S461.
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title = "Sensitivity to change of aerobic exercise parameters in children with juvenile myositis",
abstract = "Juvenile myositis (JM) is a rare disease in which the immune system targets the microvasculature of the skeletal muscle and skin, leading to significant muscle weakness and exercise intolerance. PURPOSE: To investigate the changes in aerobic exercise parameters in children with JM during an active and inactive disease (remission) period, and secondly to study the sensitivity to change of these exercise parameters.METHODS: 13 children with JM (mean±SD age: 11.2±2.6 years) participated in this study. Subjects performed a maximal exercise test using an electronically braked cycle ergometer and a calibrated respiratory gas analysis system (Jaeger Oxycon Pro). Exercise parameters that were measured and derived included: peak oxygen uptake (VO2peak), peak work rate (Wpeak), peak heart rate (HRpeak), and ventilatory anaerobic threshold (VAT). All children were tested during an active period of the disease as well as during a remission period. From these data four different responsiveness statistics were calculated: standardized response mean (SRM), Cohen's effect size (ES), paired t-tests and {\%} change from baseline.RESULTS: The children performed significantly better during the remission period compared to a period of active disease (see Table 1). Most exercise parameters showed a very large responsiveness (ES > 0.8)CONCLUSION: We found that children with JM during the active disease phase had significantly reduced exercise parameters compared to a remission period. The physiological variables were not as sensitive to change compared to work rate. This suggests some type of metabolic disconnection, which might be caused by the reduced blood flow to the active musculature.",
author = "Tim Takken and {van der Net}, Janjaap and Viswanath Unnithan and Jeneson, {Jeroen A.} and Jihaan Hassan and Suzanne Pater and Engelbert, {Raoul H.} and Helders, {Paul J.}",
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Takken, T, van der Net, J, Unnithan, V, Jeneson, JA, Hassan, J, Pater, S, Engelbert, RH & Helders, PJ 2008, 'Sensitivity to change of aerobic exercise parameters in children with juvenile myositis' Medicine & Science in Sports & Exercise, vol. 40, no. 5, pp. S461-S461. https://doi.org/10.1249/01.mss.0000322961.95713.11

Sensitivity to change of aerobic exercise parameters in children with juvenile myositis. / Takken, Tim; van der Net, Janjaap; Unnithan, Viswanath; Jeneson, Jeroen A.; Hassan, Jihaan; Pater, Suzanne; Engelbert, Raoul H.; Helders, Paul J.

In: Medicine & Science in Sports & Exercise, Vol. 40, No. 5, 05.2008, p. S461-S461.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Sensitivity to change of aerobic exercise parameters in children with juvenile myositis

AU - Takken, Tim

AU - van der Net, Janjaap

AU - Unnithan, Viswanath

AU - Jeneson, Jeroen A.

AU - Hassan, Jihaan

AU - Pater, Suzanne

AU - Engelbert, Raoul H.

AU - Helders, Paul J.

PY - 2008/5

Y1 - 2008/5

N2 - Juvenile myositis (JM) is a rare disease in which the immune system targets the microvasculature of the skeletal muscle and skin, leading to significant muscle weakness and exercise intolerance. PURPOSE: To investigate the changes in aerobic exercise parameters in children with JM during an active and inactive disease (remission) period, and secondly to study the sensitivity to change of these exercise parameters.METHODS: 13 children with JM (mean±SD age: 11.2±2.6 years) participated in this study. Subjects performed a maximal exercise test using an electronically braked cycle ergometer and a calibrated respiratory gas analysis system (Jaeger Oxycon Pro). Exercise parameters that were measured and derived included: peak oxygen uptake (VO2peak), peak work rate (Wpeak), peak heart rate (HRpeak), and ventilatory anaerobic threshold (VAT). All children were tested during an active period of the disease as well as during a remission period. From these data four different responsiveness statistics were calculated: standardized response mean (SRM), Cohen's effect size (ES), paired t-tests and % change from baseline.RESULTS: The children performed significantly better during the remission period compared to a period of active disease (see Table 1). Most exercise parameters showed a very large responsiveness (ES > 0.8)CONCLUSION: We found that children with JM during the active disease phase had significantly reduced exercise parameters compared to a remission period. The physiological variables were not as sensitive to change compared to work rate. This suggests some type of metabolic disconnection, which might be caused by the reduced blood flow to the active musculature.

AB - Juvenile myositis (JM) is a rare disease in which the immune system targets the microvasculature of the skeletal muscle and skin, leading to significant muscle weakness and exercise intolerance. PURPOSE: To investigate the changes in aerobic exercise parameters in children with JM during an active and inactive disease (remission) period, and secondly to study the sensitivity to change of these exercise parameters.METHODS: 13 children with JM (mean±SD age: 11.2±2.6 years) participated in this study. Subjects performed a maximal exercise test using an electronically braked cycle ergometer and a calibrated respiratory gas analysis system (Jaeger Oxycon Pro). Exercise parameters that were measured and derived included: peak oxygen uptake (VO2peak), peak work rate (Wpeak), peak heart rate (HRpeak), and ventilatory anaerobic threshold (VAT). All children were tested during an active period of the disease as well as during a remission period. From these data four different responsiveness statistics were calculated: standardized response mean (SRM), Cohen's effect size (ES), paired t-tests and % change from baseline.RESULTS: The children performed significantly better during the remission period compared to a period of active disease (see Table 1). Most exercise parameters showed a very large responsiveness (ES > 0.8)CONCLUSION: We found that children with JM during the active disease phase had significantly reduced exercise parameters compared to a remission period. The physiological variables were not as sensitive to change compared to work rate. This suggests some type of metabolic disconnection, which might be caused by the reduced blood flow to the active musculature.

U2 - 10.1249/01.mss.0000322961.95713.11

DO - 10.1249/01.mss.0000322961.95713.11

M3 - Meeting Abstract

VL - 40

SP - S461-S461

JO - Medicine & Science in Sports & Exercise

JF - Medicine & Science in Sports & Exercise

SN - 0195-9131

IS - 5

ER -