Screening fungal endophytes derived from under-explored Egyptian marine habitats for antimicrobial and antioxidant properties in factionalised textiles

Ahmed A. Hamed, Sylvia Soldatou, M. Mallique Qader, Subha Arjunan, Kevin Jace Miranda, Federica Casolari, Coralie Pavesi, Oluwatofunmilay A. Diyaolu, Bathini Thissera, Manal Eshelli, Lassaad Belbahri, Lenka Luptakova, Nabil A. Ibrahim, Mohamed S. Abdel-Aziz, Basma M. Eid, Mosaad A. Ghareeb, Mostafa E. Rateb*, Rainer Ebel*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)
    58 Downloads (Pure)

    Abstract

    Marine endophytic fungi from under-explored locations are a promising source for the discovery of new bioactivities. Different endophytic fungi were isolated from plants and marine organisms collected from Wadi El-Natrun saline lakes and the Red Sea near Hurghada, Egypt. The isolated strains were grown on three different media, and their ethyl acetate crude extracts were evaluated for their antimicrobial activity against a panel of pathogenic bacteria and fungi as well as their antioxidant properties. Results showed that most of the 32 fungal isolates initially obtained possessed antimicrobial and antioxidant activities. The most potent antimicrobial extracts were applied to three different cellulose containing fabrics to add new multifunctional properties such as ultraviolet protection and antimicrobial functionality. For textile safety, the toxicity profile of the selected fungal extract was evaluated on human fibroblasts. The 21 strains displaying bioactivity were identified on molecular basis and selected for chemical screening and dereplication, which was carried out by analysis of the MS/MS data using the Global Natural Products Social Molecular Networking (GNPS) platform. The obtained molecular network revealed molecular families of compounds commonly produced by fungal strains, and in combination with manual dereplication, further previously reported metabolites were identified as well as potentially new derivatives.
    Original languageEnglish
    Article number1617
    Number of pages19
    JournalMicroorganisms
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - 21 Oct 2020

    Keywords

    • endophytic fungi
    • antimicrobial
    • antioxidant
    • GNPS
    • textiles

    Fingerprint

    Dive into the research topics of 'Screening fungal endophytes derived from under-explored Egyptian marine habitats for antimicrobial and antioxidant properties in factionalised textiles'. Together they form a unique fingerprint.

    Cite this