Screening fungal endophytes derived from under-explored Egyptian marine habitats for antimicrobial and antioxidant properties in factionalised textiles

Ahmed A. Hamed, Sylvia Soldatou, M. Mallique Qader, Subha Arjunan, Kevin Jace Miranda, Federica Casolari, Coralie Pavesi, Oluwatofunmilay A. Diyaolu, Bathini Thissera, Manal Eshelli, Lassaad Belbahri, Lenka Luptakova, Nabil A. Ibrahim, Mohamed S. Abdel-Aziz, Basma M. Eid, Mosaad A. Ghareeb, Mostafa E. Rateb*, Rainer Ebel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
9 Downloads (Pure)

Abstract

Marine endophytic fungi from under-explored locations are a promising source for the discovery of new bioactivities. Different endophytic fungi were isolated from plants and marine organisms collected from Wadi El-Natrun saline lakes and the Red Sea near Hurghada, Egypt. The isolated strains were grown on three different media, and their ethyl acetate crude extracts were evaluated for their antimicrobial activity against a panel of pathogenic bacteria and fungi as well as their antioxidant properties. Results showed that most of the 32 fungal isolates initially obtained possessed antimicrobial and antioxidant activities. The most potent antimicrobial extracts were applied to three different cellulose containing fabrics to add new multifunctional properties such as ultraviolet protection and antimicrobial functionality. For textile safety, the toxicity profile of the selected fungal extract was evaluated on human fibroblasts. The 21 strains displaying bioactivity were identified on molecular basis and selected for chemical screening and dereplication, which was carried out by analysis of the MS/MS data using the Global Natural Products Social Molecular Networking (GNPS) platform. The obtained molecular network revealed molecular families of compounds commonly produced by fungal strains, and in combination with manual dereplication, further previously reported metabolites were identified as well as potentially new derivatives.
Original languageEnglish
Article number1617
Number of pages19
JournalMicroorganisms
Volume8
Issue number10
DOIs
Publication statusPublished - 21 Oct 2020

Keywords

  • endophytic fungi
  • antimicrobial
  • antioxidant
  • GNPS
  • textiles

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