Relación entre infarto de miocardio y ritmo circadiano en pacientes atendidos por un servicio de emergencias prehospitalario

Translated title of the contribution: Relation between myocardial infarction and cyrcadian rhythm in patients attended in a prehospital emergency service

Maria Cristina Barneto Valero, Jose Ramon Garmendia Leiza, Julio Ardura Fernandez, Juan Pablo Casaseca de la Higuera, Jesus Maria Andres de Llano, Ervigio Corral Torres

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background and objectives: The aim of this study is to analyze the presence of circadian rhythm in the time of onset of symptoms of acute myocardial infarction treated by a prehospital emergency system and the influence of modifiable cardiovascular risk factors and non-modifiable as modulators of that circadian rhythm. Patients and methods: Retrospective analysis of 709 patients clinically diagnosed with acute myocardial infarction on-site in the prehospital setting. The variables were time to onset of symptoms, age, sex, previous ischemic heart disease, hypertension, diabetes mellitus, hyperlipidemia and smoking. We analyzed the rhythm with cosinor multiple sinusoid method, with 3 harmonics (24, 12 and 8 h) for the adjustment. Results: The time of onset of pain showed circadian rhythm (P <.001), peaking at 10.39 and a valley at 4.28, showing a sinusoidal curve fitting bimodal aspect with a predominant morning peak and another evening one of lower amplitude. All subgroups categorized by the study variables showed circadian rhythm, with a cosine curve similar to the global infarction. Smokers had a predominantly evening peak. Conclusions: Acute myocardial infarction shows a circadian rhythm. Smoking and diabetes mellitus can modify the standard incidence rate of occurrence of myocardial infarction.
Translated title of the contributionRelation between myocardial infarction and cyrcadian rhythm in patients attended in a prehospital emergency service
Original languageSpanish
Pages (from-to)515-521
Number of pages7
JournalMedicina Clínica
Issue number12
Publication statusPublished - 17 Nov 2012
Externally publishedYes


  • Circadian rhythm
  • Acute myocardial infarction
  • Cardiovascular risk factors
  • Prehospital emergency system

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