Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection

Laura Denney, Celia Aitken, Chris Ka-Fai Li, Eleri Wilson-Davies, Wai Ling Kok, Colin Clelland, Kevin Rooney, Duncan Young, Tao Dong, Andrew J. McMichael, William F. Carman, Ling-Pei Ho

Research output: Contribution to journalArticle

Abstract

Background
The cause of severe disease in some patients infected with pandemic influenza A virus is unclear.

Methodology/Principal Findings
We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients.

Conclusion/Significance
Our report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype.
Original languageEnglish
JournalPLoS ONE
Volume5
Issue number5
DOIs
Publication statusPublished - May 2010
Externally publishedYes

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T-cells
Influenza A virus
Virus Diseases
Viruses
natural killer cells
Immunology
Natural Killer Cells
infection
Blood
T-lymphocytes
T-Lymphocytes
Viremia
viremia
Pandemics
pandemic
viral load
Allergy and Immunology
Viral Load
immunology
Control Groups

Cite this

Denney, Laura ; Aitken, Celia ; Li, Chris Ka-Fai ; Wilson-Davies, Eleri ; Kok, Wai Ling ; Clelland, Colin ; Rooney, Kevin ; Young, Duncan ; Dong, Tao ; McMichael, Andrew J. ; Carman, William F. ; Ho, Ling-Pei. / Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection. In: PLoS ONE. 2010 ; Vol. 5, No. 5.
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title = "Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection",
abstract = "BackgroundThe cause of severe disease in some patients infected with pandemic influenza A virus is unclear.Methodology/Principal FindingsWe present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients.Conclusion/SignificanceOur report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype.",
author = "Laura Denney and Celia Aitken and Li, {Chris Ka-Fai} and Eleri Wilson-Davies and Kok, {Wai Ling} and Colin Clelland and Kevin Rooney and Duncan Young and Tao Dong and McMichael, {Andrew J.} and Carman, {William F.} and Ling-Pei Ho",
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Denney, L, Aitken, C, Li, CK-F, Wilson-Davies, E, Kok, WL, Clelland, C, Rooney, K, Young, D, Dong, T, McMichael, AJ, Carman, WF & Ho, L-P 2010, 'Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection' PLoS ONE, vol. 5, no. 5. https://doi.org/10.1371/journal.pone.0010675

Reduction of Natural Killer but Not Effector CD8 T Lymphoyctes in Three Consecutive Cases of Severe/Lethal H1N1/09 Influenza A Virus Infection. / Denney, Laura; Aitken, Celia; Li, Chris Ka-Fai ; Wilson-Davies, Eleri; Kok, Wai Ling ; Clelland, Colin; Rooney, Kevin; Young, Duncan; Dong, Tao; McMichael, Andrew J. ; Carman, William F. ; Ho, Ling-Pei.

In: PLoS ONE, Vol. 5, No. 5, 05.2010.

Research output: Contribution to journalArticle

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AU - Denney, Laura

AU - Aitken, Celia

AU - Li, Chris Ka-Fai

AU - Wilson-Davies, Eleri

AU - Kok, Wai Ling

AU - Clelland, Colin

AU - Rooney, Kevin

AU - Young, Duncan

AU - Dong, Tao

AU - McMichael, Andrew J.

AU - Carman, William F.

AU - Ho, Ling-Pei

PY - 2010/5

Y1 - 2010/5

N2 - BackgroundThe cause of severe disease in some patients infected with pandemic influenza A virus is unclear.Methodology/Principal FindingsWe present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients.Conclusion/SignificanceOur report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype.

AB - BackgroundThe cause of severe disease in some patients infected with pandemic influenza A virus is unclear.Methodology/Principal FindingsWe present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients.Conclusion/SignificanceOur report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype.

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