Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

Jonathan Baker, Adrian Falconer, David J. Wilkinson, G. Nicholas Europe-Finner, Gary Litherland, Andrew D. Rowan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Research Output

  • 9 Citations
  • 10 Article
  • 3 Meeting Abstract
2018

Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes

Macdonald, C. D., Falconer, A. M. D., Chan, C. M., Wilkinson, D. J., Skelton, A., Reynard, L., Litherland, G. J., Europe-Finner, G. N. & Rowan, A. D., 15 Nov 2018, In : PLoS ONE. 13, 11, 16 p., e0207240.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
6 Downloads (Pure)
2016

Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation

Chan, C. M., Macdonald, C. D., Litherland, G., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N. & Rowan, A. D., 12 Dec 2016, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
2014

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

Litherland, G. J., Hui, W., Elias, M. S., Wilkinson, D. J., Watson, S., Huesa, C., Young, D. A. & Rowan, A. D., Aug 2014, In : Arthritis & Rheumatology. 66, 8, p. 2175-2187

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)
2013

The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes

Baker, J., Litherland, G. J. & Rowan, A. D., Apr 2013, In : Rheumatology. 52, S1, p. S49-S49 1 p.

Research output: Contribution to journalMeeting Abstract

2012

Glycogen synthase kinase-3 as a gatekeeper of human cartilage degradation

Litherland, G. J., Elias, M. S., Curtis, H. & Rowan, A. D., 1 Aug 2012, In : International Journal of Experimental Pathology. 93, 4, p. A31-A31

Research output: Contribution to journalMeeting Abstract

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

Hui, W., Litherland, G. J., Elias, M. S., Kitson, G. I., Cawston, T. E., Rowan, A. D. & Young, D. A., Mar 2012, In : Annals of the Rheumatic Diseases. 71, 3, p. 455-62 8 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)
2010

HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes

Barter, M. J., Pybus, L., Litherland, G. J., Rowan, A. D., Clark, I. M., Edwards, D. R., Cawston, T. E. & Young, D. A., Sep 2010, In : Matrix Biology. 29, 7, p. 602-612

Research output: Contribution to journalArticle

57 Citations (Scopus)

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway

Hui, W., Litherland, G. J., Jefferson, M., Barter, M. J., Elias, M. S., Cawston, T. E., Rowan, A. D. & Young, D. A., Nov 2010, In : Rheumatology. 49, 11, p. 2043-2053

Research output: Contribution to journalArticle

30 Citations (Scopus)

Protein Kinase C Isoforms zeta and iota Mediate Collagenase Expression and Cartilage Destruction via STAT3-and ERK-dependent c-fos Induction

Litherland, G. J., Elias, M. S., Hui, W., Macdonald, C. D., Catterall, J. B., Barter, M. J., Farren, M. J., Jefferson, M. & Rowan, A. D., 16 Jul 2010, In : Journal of Biological Chemistry. 285, 29, p. 22414-22425

Research output: Contribution to journalArticle

Open Access
40 Citations (Scopus)
2009

Role of protein kinase C isoforms in collagenase induction and cartilage degradation

Rowan, A. D. & Litherland, G., 2009, In : Osteoarthritis and Cartilage. 17, Supplement 1, p. S146

Research output: Contribution to journalMeeting Abstract

Open Access
2008

Differential Toll-like receptor-dependent collagenase expression in chondrocytes

Zhang, Q., Hui, W., Litherland, G. J., Barter, M. J., Davidson, R., Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. & Young, D. A., Nov 2008, In : Annals of the Rheumatic Diseases. 67, 11, p. 1633-1641

Research output: Contribution to journalArticle

74 Citations (Scopus)

Metalloproteases as potential therapeutic targets in arthritis treatment

Rowan, A. D., Litherland, G. J., Hui, W. & Milner, J. M., Jan 2008, In : Expert Opinion on Therapeutic Targets. 12, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent

Litherland, G. J., Dixon, C., Lakey, R. L., Robson, T., Jones, D., Young, D. A., Cawston, T. E. & Rowan, A. D., 23 May 2008, In : Journal of Biological Chemistry. 283, 21, p. 14221-14229 9 p.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)