Protein adsorption studied by neutron reflection

Jian R. Lu*, Xiubo Zhao, M. Yaseen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

This article reviews recent development in the use of neutron reflection to study protein adsorption. The phenomenon of protein adsorption will be introduced, followed by the outline of the technological relevance of the interfacial molecular events. As lysozyme and albumins are widely used in recent adsorption studies, these model systems will be taken to demonstrate how interfacial structural details are affected by different surface chemical nature. The prospect of neutron reflection in revealing interfacial structural conformations of biologically more relevant proteins is highlighted.
Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume12
Issue number1
DOIs
Publication statusPublished - 28 Feb 2007
Externally publishedYes

Keywords

  • protein adsorption
  • neutron reflection
  • surface
  • interface
  • protein unfolding
  • denaturation
  • ECM proteins
  • enzyme immobilisation
  • surface cleaning
  • thim films
  • protein surfactant

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