Potential cellular and biochemical mechanisms of exercise and physical activity on the ageing process

Mark Ross*, Hannah Lithgow, Lawrence Hayes, Geraint Florida-James

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)
6 Downloads (Pure)


Exercise in young adults has been consistently shown to improve various aspects of physiological and psychological health but we are now realising the potential benefits of exercise with advancing age. Specifically, exercise improves cardiovascular, musculoskeletal, and metabolic health through reductions in oxidative stress, chronic low-grade inflammation and modulating cellular processes within a variety of tissues. In this this chapter we will discuss the effects of acute and chronic exercise on these processes and conditions in an ageing population, and how physical activity affects our vasculature, skeletal muscle function, our immune system, and cardiometabolic risk in older adults.

Original languageEnglish
Title of host publicationBiochemistry and Cell Biology of Ageing
Subtitle of host publicationPart II Clinical Science
EditorsJ. Robin Harris, Viktor I. Korolchuk
Place of PublicationSingapore
PublisherSpringer Nature Singapore Pte Ltd
Number of pages28
ISBN (Electronic)9789811336812
ISBN (Print)9789811336805
Publication statusE-pub ahead of print - 20 Mar 2019
Externally publishedYes

Publication series

NameSubcellular Biochemistry
ISSN (Print)0306-0225


  • Ageing
  • Atrophy
  • Bone health
  • Cardiovascular disease
  • Endothelial function
  • Exercise
  • Immunology
  • Insulin resistance
  • Oxidative stress
  • Physical activity
  • Sarcopenia
  • Skeletal muscle
  • Tissue regeneration


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