Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men

Lawrence D. Hayes, Nicholas Sculthorpe, Peter Herbert, Julien S. Baker, David A. Hullin, Liam P. Kilduff, Fergal M. Grace

Research output: Contribution to journalArticle

Abstract

Testosterone (T) is a biologically important androgen that demonstrates a widely-known natural decline with advancing age. The use of salivary T (sal-T), as a determinant of systemic T, has shown promising results in recent years. However, the strength of the salivary-serum T relationship may be affected by measurement method and binding capacity with salivary proteins. The potential influence exercise may impact on this relationship is unstudied in aging men. Therefore, the aim of the present investigation was to examine the relationship of the delta change (Delta) in sal-T with Delta serum T following six weeks exercise training. Fifteen sedentary (SED) males (aged 60.4 +/- 5.0 years of age) and 20 lifelong exercising (LE) males (60.4 +/- 4.7 years of age) were participated. Pearson's correlation coefficient revealed sal-T did not correlate with total testosterone (TT), sex hormone binding globulin (SHBG), bioactive T (bio-T), or free T (free-T) at week 0 or week 6. Delta sal-T did not correlate with Delta TT, Delta SHBG, Delta bio-T or Delta free-T (r=0.271, p=0.180; r=0.197, p=0.335; r=0.258, p=0.205; and r=0.257, p=0.205, respectively). In conclusion, poor levels of agreement existed between saliva and serum measurements of T in response to exercise amongst aging men.
Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalThe Aging Male
Volume18
Issue number2
DOIs
Publication statusPublished - Jun 2015

Keywords

  • Aging
  • exercise
  • saliva
  • sex hormone binding globulin
  • testosterone

Cite this

Hayes, Lawrence D. ; Sculthorpe, Nicholas ; Herbert, Peter ; Baker, Julien S. ; Hullin, David A. ; Kilduff, Liam P. ; Grace, Fergal M. / Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men. In: The Aging Male. 2015 ; Vol. 18, No. 2. pp. 67-70.
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Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men. / Hayes, Lawrence D.; Sculthorpe, Nicholas; Herbert, Peter; Baker, Julien S.; Hullin, David A.; Kilduff, Liam P.; Grace, Fergal M.

In: The Aging Male, Vol. 18, No. 2, 06.2015, p. 67-70.

Research output: Contribution to journalArticle

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AU - Hayes, Lawrence D.

AU - Sculthorpe, Nicholas

AU - Herbert, Peter

AU - Baker, Julien S.

AU - Hullin, David A.

AU - Kilduff, Liam P.

AU - Grace, Fergal M.

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N2 - Testosterone (T) is a biologically important androgen that demonstrates a widely-known natural decline with advancing age. The use of salivary T (sal-T), as a determinant of systemic T, has shown promising results in recent years. However, the strength of the salivary-serum T relationship may be affected by measurement method and binding capacity with salivary proteins. The potential influence exercise may impact on this relationship is unstudied in aging men. Therefore, the aim of the present investigation was to examine the relationship of the delta change (Delta) in sal-T with Delta serum T following six weeks exercise training. Fifteen sedentary (SED) males (aged 60.4 +/- 5.0 years of age) and 20 lifelong exercising (LE) males (60.4 +/- 4.7 years of age) were participated. Pearson's correlation coefficient revealed sal-T did not correlate with total testosterone (TT), sex hormone binding globulin (SHBG), bioactive T (bio-T), or free T (free-T) at week 0 or week 6. Delta sal-T did not correlate with Delta TT, Delta SHBG, Delta bio-T or Delta free-T (r=0.271, p=0.180; r=0.197, p=0.335; r=0.258, p=0.205; and r=0.257, p=0.205, respectively). In conclusion, poor levels of agreement existed between saliva and serum measurements of T in response to exercise amongst aging men.

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