Testosterone (T) is a biologically important androgen that demonstrates a widely-known natural decline with advancing age. The use of salivary T (sal-T), as a determinant of systemic T, has shown promising results in recent years. However, the strength of the salivary-serum T relationship may be affected by measurement method and binding capacity with salivary proteins. The potential influence exercise may impact on this relationship is unstudied in aging men. Therefore, the aim of the present investigation was to examine the relationship of the delta change (Delta) in sal-T with Delta serum T following six weeks exercise training. Fifteen sedentary (SED) males (aged 60.4 +/- 5.0 years of age) and 20 lifelong exercising (LE) males (60.4 +/- 4.7 years of age) were participated. Pearson's correlation coefficient revealed sal-T did not correlate with total testosterone (TT), sex hormone binding globulin (SHBG), bioactive T (bio-T), or free T (free-T) at week 0 or week 6. Delta sal-T did not correlate with Delta TT, Delta SHBG, Delta bio-T or Delta free-T (r=0.271, p=0.180; r=0.197, p=0.335; r=0.258, p=0.205; and r=0.257, p=0.205, respectively). In conclusion, poor levels of agreement existed between saliva and serum measurements of T in response to exercise amongst aging men.
- sex hormone binding globulin
Hayes, L. D., Sculthorpe, N., Herbert, P., Baker, J. S., Hullin, D. A., Kilduff, L. P., & Grace, F. M. (2015). Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men. The Aging Male, 18(2), 67-70. https://doi.org/10.3109/13685538.2015.1018158