Polymicrobial Candida biofilms: friends and foe in the oral cavity

Lindsay O’Donnell, Emma Millhouse, Leighann Sherry, Ryan Kean, Jennifer Malcolm, Christopher Nile, Gordon Ramage

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


The role of polymicrobial biofilm infections in medicine is becoming more apparent. Increasing number of microbiome studies and deep sequencing has enabled us to develop a greater understanding of how positive and negative microbial interactions influence disease outcomes. An environment where this is particularly pertinent is within the oral cavity, a rich and diverse ecosystem inhabited by both bacteria and yeasts, which collectively occupy and coexist within various niches as biofilm communities. Studies within this environment have however tended to be subject to extensive independent investigation, in the context of either polymicrobial bacterial communities or yeast biofilms, but rarely both together. It is clear however that they are not mutually exclusive. Therefore, this review aims to explore the influence of candidal populations on the composition of these complex aggregates and biofilm communities, to investigate their mechanistic interactions to understand how these impact clinical outcomes, and determine whether we can translate how this knowledge can be used to improve patient management.
Original languageEnglish
JournalFEMS Yeast Research
Issue number7
Early online date15 Sep 2015
Publication statusPublished - 1 Nov 2015
Externally publishedYes


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