Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency

M.R. Graham, J.S. Baker, P. Evans, A. Kicman, D. Cowan, D. Hullin, N. Thomas, B. Davies

Research output: Contribution to journalArticle

Abstract

Background/Aims

Recombinant human growth hormone (rhGH) as opposed to cadaver pituitary GH is misused for physical improvement. Six days’ rhGH administration, in abstinent anabolic-androgenic steroid dependents, was compared with controls. 
Method
Male subjects (n = 48) were randomly divided into two groups: (1): control group (C), n = 24, mean ± SD, age 32 ± 11 years, height 1.8 ± 0.06 m; (2): rhGH-using group (0.058 IU·kg–1·day–1) (GH), n = 24, mean ± SD, age 32 ± 9 years, height 1.8 ± 0.07 m. Physiological measurements included anthropometry, strength, power and peak oxygen uptake (VO2 peak). Biochemical measurements included haemoglobin, packed cell volume, glucose, sodium, potassium, urea, creatinine, total protein, albumin, thyroid function, testosterone, prolactin, cortisol, GH and insulin-like growth factor-I (IGF-I). 
Results
Strength, peak power output and IGF-I significantly increased and total protein, albumin and free tetra-iodothyronine significantly decreased compared to controls (p < 0.05) and within the GH group (p < 0.017). Fat-free mass index and VO2 peak significantly increased, while body fat and thyroid-stimulating hormone significantly decreased within the GH group (p < 0.017). 
Conclusions
Short-term rhGH increased strength and power. Of therapeutic value is the possibility that muscle bulk and strength could be increased in patients with muscle-wasting conditions.
Original languageEnglish
Pages (from-to)343-354
Number of pages12
JournalHormone Research
Volume69
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Human Growth Hormone
Insulin-Like Growth Factor I
Growth Hormone
Albumins
Testosterone Congeners
Steroids
Anthropometry
Muscle Strength
Thyrotropin
Cell Size
Cadaver
Prolactin
Hydrocortisone
Urea
Testosterone
Adipose Tissue
Creatinine
Potassium
Thyroid Gland
Hemoglobins

Keywords

  • insulin-like growth factor-1
  • physical stress
  • recombinant human growth hormone
  • strength

Cite this

Graham, M. R., Baker, J. S., Evans, P., Kicman, A., Cowan, D., Hullin, D., ... Davies, B. (2008). Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency. Hormone Research, 69, 343-354. https://doi.org/10.1159/000117390
Graham, M.R. ; Baker, J.S. ; Evans, P. ; Kicman, A. ; Cowan, D. ; Hullin, D. ; Thomas, N. ; Davies, B. / Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency. In: Hormone Research. 2008 ; Vol. 69. pp. 343-354.
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abstract = "Background/AimsRecombinant human growth hormone (rhGH) as opposed to cadaver pituitary GH is misused for physical improvement. Six days’ rhGH administration, in abstinent anabolic-androgenic steroid dependents, was compared with controls. MethodMale subjects (n = 48) were randomly divided into two groups: (1): control group (C), n = 24, mean ± SD, age 32 ± 11 years, height 1.8 ± 0.06 m; (2): rhGH-using group (0.058 IU·kg–1·day–1) (GH), n = 24, mean ± SD, age 32 ± 9 years, height 1.8 ± 0.07 m. Physiological measurements included anthropometry, strength, power and peak oxygen uptake (VO2 peak). Biochemical measurements included haemoglobin, packed cell volume, glucose, sodium, potassium, urea, creatinine, total protein, albumin, thyroid function, testosterone, prolactin, cortisol, GH and insulin-like growth factor-I (IGF-I). ResultsStrength, peak power output and IGF-I significantly increased and total protein, albumin and free tetra-iodothyronine significantly decreased compared to controls (p < 0.05) and within the GH group (p < 0.017). Fat-free mass index and VO2 peak significantly increased, while body fat and thyroid-stimulating hormone significantly decreased within the GH group (p < 0.017). ConclusionsShort-term rhGH increased strength and power. Of therapeutic value is the possibility that muscle bulk and strength could be increased in patients with muscle-wasting conditions.",
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Graham, MR, Baker, JS, Evans, P, Kicman, A, Cowan, D, Hullin, D, Thomas, N & Davies, B 2008, 'Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency', Hormone Research, vol. 69, pp. 343-354. https://doi.org/10.1159/000117390

Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency. / Graham, M.R.; Baker, J.S.; Evans, P. ; Kicman, A.; Cowan, D.; Hullin, D.; Thomas, N.; Davies, B.

In: Hormone Research, Vol. 69, 2008, p. 343-354.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency

AU - Graham, M.R.

AU - Baker, J.S.

AU - Evans, P.

AU - Kicman, A.

AU - Cowan, D.

AU - Hullin, D.

AU - Thomas, N.

AU - Davies, B.

PY - 2008

Y1 - 2008

N2 - Background/AimsRecombinant human growth hormone (rhGH) as opposed to cadaver pituitary GH is misused for physical improvement. Six days’ rhGH administration, in abstinent anabolic-androgenic steroid dependents, was compared with controls. MethodMale subjects (n = 48) were randomly divided into two groups: (1): control group (C), n = 24, mean ± SD, age 32 ± 11 years, height 1.8 ± 0.06 m; (2): rhGH-using group (0.058 IU·kg–1·day–1) (GH), n = 24, mean ± SD, age 32 ± 9 years, height 1.8 ± 0.07 m. Physiological measurements included anthropometry, strength, power and peak oxygen uptake (VO2 peak). Biochemical measurements included haemoglobin, packed cell volume, glucose, sodium, potassium, urea, creatinine, total protein, albumin, thyroid function, testosterone, prolactin, cortisol, GH and insulin-like growth factor-I (IGF-I). ResultsStrength, peak power output and IGF-I significantly increased and total protein, albumin and free tetra-iodothyronine significantly decreased compared to controls (p < 0.05) and within the GH group (p < 0.017). Fat-free mass index and VO2 peak significantly increased, while body fat and thyroid-stimulating hormone significantly decreased within the GH group (p < 0.017). ConclusionsShort-term rhGH increased strength and power. Of therapeutic value is the possibility that muscle bulk and strength could be increased in patients with muscle-wasting conditions.

AB - Background/AimsRecombinant human growth hormone (rhGH) as opposed to cadaver pituitary GH is misused for physical improvement. Six days’ rhGH administration, in abstinent anabolic-androgenic steroid dependents, was compared with controls. MethodMale subjects (n = 48) were randomly divided into two groups: (1): control group (C), n = 24, mean ± SD, age 32 ± 11 years, height 1.8 ± 0.06 m; (2): rhGH-using group (0.058 IU·kg–1·day–1) (GH), n = 24, mean ± SD, age 32 ± 9 years, height 1.8 ± 0.07 m. Physiological measurements included anthropometry, strength, power and peak oxygen uptake (VO2 peak). Biochemical measurements included haemoglobin, packed cell volume, glucose, sodium, potassium, urea, creatinine, total protein, albumin, thyroid function, testosterone, prolactin, cortisol, GH and insulin-like growth factor-I (IGF-I). ResultsStrength, peak power output and IGF-I significantly increased and total protein, albumin and free tetra-iodothyronine significantly decreased compared to controls (p < 0.05) and within the GH group (p < 0.017). Fat-free mass index and VO2 peak significantly increased, while body fat and thyroid-stimulating hormone significantly decreased within the GH group (p < 0.017). ConclusionsShort-term rhGH increased strength and power. Of therapeutic value is the possibility that muscle bulk and strength could be increased in patients with muscle-wasting conditions.

KW - insulin-like growth factor-1

KW - physical stress

KW - recombinant human growth hormone

KW - strength

U2 - 10.1159/000117390

DO - 10.1159/000117390

M3 - Article

VL - 69

SP - 343

EP - 354

JO - Hormone Research

JF - Hormone Research

SN - 0301-0163

ER -