Peptidases in autophagy are therapeutic targets for Leishmaniasis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Differentiation of Leishmania life forms is crucial for progression and preadaptation of the parasite to the environmental conditions existing in its hosts. Autophagy is a catabolic degradation process that utilizes cytosolic ATG4s and lysosomal cathepsins to affect protein turnover and remodeling, which are crucial for parasite development, differentiation, and virulence. In this chapter, published data on the physiological roles of the cysteine peptidases involved in autophagy and virulence in Leishmania spp. that establishes them as therapeutic targets will be reviewed. Potential lead compounds that can modulate the activities of the cysteine peptidases for therapeutic advantage, the challenges involved, and the opportunities they provide for drug development to control leishmaniasis will be discussed.
Original languageEnglish
Title of host publicationTrypanosomatid Diseases
Subtitle of host publicationMolecular Routes to Drug Discovery
EditorsTimo Jäger, Oliver Koch, Leopold Flohé
Place of PublicationWeinheim
PublisherWiley-VCH Verlag
Pages351-364
Number of pages14
ISBN (Electronic)9783527670383
ISBN (Print)9783527332557
DOIs
Publication statusPublished - 17 Apr 2013

Publication series

NameDrug Discovery in Infectious Diseases

Keywords

  • cysteine peptidase
  • autophagy
  • virulence
  • drug development
  • leishmaniasis
  • cathepsin

Cite this

Williams, R. A. M. (2013). Peptidases in autophagy are therapeutic targets for Leishmaniasis. In T. Jäger, O. Koch, & L. Flohé (Eds.), Trypanosomatid Diseases: Molecular Routes to Drug Discovery (pp. 351-364). (Drug Discovery in Infectious Diseases). Weinheim: Wiley-VCH Verlag. https://doi.org/10.1002/9783527670383.ch19
Williams, Roderick A.M. / Peptidases in autophagy are therapeutic targets for Leishmaniasis. Trypanosomatid Diseases: Molecular Routes to Drug Discovery. editor / Timo Jäger ; Oliver Koch ; Leopold Flohé. Weinheim : Wiley-VCH Verlag, 2013. pp. 351-364 (Drug Discovery in Infectious Diseases).
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Williams, RAM 2013, Peptidases in autophagy are therapeutic targets for Leishmaniasis. in T Jäger, O Koch & L Flohé (eds), Trypanosomatid Diseases: Molecular Routes to Drug Discovery. Drug Discovery in Infectious Diseases, Wiley-VCH Verlag, Weinheim, pp. 351-364. https://doi.org/10.1002/9783527670383.ch19

Peptidases in autophagy are therapeutic targets for Leishmaniasis. / Williams, Roderick A.M.

Trypanosomatid Diseases: Molecular Routes to Drug Discovery. ed. / Timo Jäger; Oliver Koch; Leopold Flohé. Weinheim : Wiley-VCH Verlag, 2013. p. 351-364 (Drug Discovery in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - Differentiation of Leishmania life forms is crucial for progression and preadaptation of the parasite to the environmental conditions existing in its hosts. Autophagy is a catabolic degradation process that utilizes cytosolic ATG4s and lysosomal cathepsins to affect protein turnover and remodeling, which are crucial for parasite development, differentiation, and virulence. In this chapter, published data on the physiological roles of the cysteine peptidases involved in autophagy and virulence in Leishmania spp. that establishes them as therapeutic targets will be reviewed. Potential lead compounds that can modulate the activities of the cysteine peptidases for therapeutic advantage, the challenges involved, and the opportunities they provide for drug development to control leishmaniasis will be discussed.

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Williams RAM. Peptidases in autophagy are therapeutic targets for Leishmaniasis. In Jäger T, Koch O, Flohé L, editors, Trypanosomatid Diseases: Molecular Routes to Drug Discovery. Weinheim: Wiley-VCH Verlag. 2013. p. 351-364. (Drug Discovery in Infectious Diseases). https://doi.org/10.1002/9783527670383.ch19