Our current understanding of fungal biofilms

Gordon Ramage, Eilidh Mowat, Brian Jones, Craig Williams, Jose Lopez-Ribot

Research output: Contribution to journalArticlepeer-review

329 Citations (Scopus)

Abstract

Fungal biofilms are an escalating clinical problem associated with significant rates of mortality. Candida albicans is the most notorious of all fungal biofilm formers. However, non-Candida species, yeasts such as Cryptococcus neoformans, and filamentous moulds such as Aspergillus fumigatus, have been shown to be implicated in biofilm-associated infections. Fungal biofilms have distinct developmental phases, including adhesion, colonisation, maturation and dispersal, which are governed by complex molecular events. Recalcitrance to antifungal therapy remains the greatest threat to patients with fungal biofilms. This review discusses our current understanding of the basic biology and clinical implications associated with fungal biofilms.

Original languageEnglish
Pages (from-to)340-55
Number of pages16
JournalCritical Reviews in Microbiology
Volume35
Issue number4
DOIs
Publication statusPublished - 28 Oct 2009
Externally publishedYes

Keywords

  • Animals
  • Biofilms
  • Fungal Proteins
  • Fungi
  • Humans
  • Mycoses
  • Candida
  • Aspergillus
  • Antifungal

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