On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I-IV

M. K. Vasilopoulou, I. Vogiatzis, I. Nasis, S. Spetsioti, E. Cherouveim, M. Koskolou, E. A. Kortianou, Z. Louvaris, G. Kaltsakas, A. Koutsoukou, N. G. Koulouris, M. Alchanatis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Exercise-induced dynamic hyperinflation and large intrathoracic pressure swings may compromise the normal increase in cardiac output (Q) in Chronic Obstructive Pulmonary Disease (COPD). Therefore, it is anticipated that the greater the disease severity, the greater would be the impairment in cardiac output during exercise. Eighty COPD patients (20 at each GOLD Stage) and 10 healthy age-matched individuals undertook a constant-load test on a cycle-ergometer (75% WRpeak) and a 6 min walking test (6MWT). Cardiac output was measured by bioimpedance (PhysioFlow, Enduro) to determine the mean response time at the onset of exercise (MRTon) and during recovery (MRToff). Whilst cardiac output mean response time was not different between the two exercise protocols, MRT responses during cycling were slower in GOLD Stages III and IV compared to Stages land II (MRTon: Stage 1:45 2, Stage II: 65 3, Stage 111: 90 3, Stage IV: 106 +/- 3 s; MRToff: Stage I: 42 +/- 2, Stage II: 68 +/- 3. Stage III: 87 +/- 3, Stage IV: 104 +/- 3 s, respectively). In conclusion, the more advanced the disease severity the more impaired is the hemodynamic response to constant-load exercise and the 6MWT, possibly reflecting greater cardiovascular impairment and/or greater physical deconditioning.
Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalRespiratory Physiology & Neurobiology
Volume181
Issue number3
DOIs
Publication statusPublished - 31 May 2012
Externally publishedYes

Keywords

  • Cardiac output
  • COPD
  • Hemodynamic kinetic responses

Cite this

Vasilopoulou, M. K. ; Vogiatzis, I. ; Nasis, I. ; Spetsioti, S. ; Cherouveim, E. ; Koskolou, M. ; Kortianou, E. A. ; Louvaris, Z. ; Kaltsakas, G. ; Koutsoukou, A. ; Koulouris, N. G. ; Alchanatis, M. / On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I-IV. In: Respiratory Physiology & Neurobiology. 2012 ; Vol. 181, No. 3. pp. 351-358.
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abstract = "Exercise-induced dynamic hyperinflation and large intrathoracic pressure swings may compromise the normal increase in cardiac output (Q) in Chronic Obstructive Pulmonary Disease (COPD). Therefore, it is anticipated that the greater the disease severity, the greater would be the impairment in cardiac output during exercise. Eighty COPD patients (20 at each GOLD Stage) and 10 healthy age-matched individuals undertook a constant-load test on a cycle-ergometer (75{\%} WRpeak) and a 6 min walking test (6MWT). Cardiac output was measured by bioimpedance (PhysioFlow, Enduro) to determine the mean response time at the onset of exercise (MRTon) and during recovery (MRToff). Whilst cardiac output mean response time was not different between the two exercise protocols, MRT responses during cycling were slower in GOLD Stages III and IV compared to Stages land II (MRTon: Stage 1:45 2, Stage II: 65 3, Stage 111: 90 3, Stage IV: 106 +/- 3 s; MRToff: Stage I: 42 +/- 2, Stage II: 68 +/- 3. Stage III: 87 +/- 3, Stage IV: 104 +/- 3 s, respectively). In conclusion, the more advanced the disease severity the more impaired is the hemodynamic response to constant-load exercise and the 6MWT, possibly reflecting greater cardiovascular impairment and/or greater physical deconditioning.",
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Vasilopoulou, MK, Vogiatzis, I, Nasis, I, Spetsioti, S, Cherouveim, E, Koskolou, M, Kortianou, EA, Louvaris, Z, Kaltsakas, G, Koutsoukou, A, Koulouris, NG & Alchanatis, M 2012, 'On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I-IV', Respiratory Physiology & Neurobiology, vol. 181, no. 3, pp. 351-358. https://doi.org/10.1016/j.resp.2012.03.014

On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I-IV. / Vasilopoulou, M. K.; Vogiatzis, I.; Nasis, I.; Spetsioti, S.; Cherouveim, E.; Koskolou, M.; Kortianou, E. A.; Louvaris, Z.; Kaltsakas, G.; Koutsoukou, A.; Koulouris, N. G.; Alchanatis, M.

In: Respiratory Physiology & Neurobiology, Vol. 181, No. 3, 31.05.2012, p. 351-358.

Research output: Contribution to journalArticle

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T1 - On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I-IV

AU - Vasilopoulou, M. K.

AU - Vogiatzis, I.

AU - Nasis, I.

AU - Spetsioti, S.

AU - Cherouveim, E.

AU - Koskolou, M.

AU - Kortianou, E. A.

AU - Louvaris, Z.

AU - Kaltsakas, G.

AU - Koutsoukou, A.

AU - Koulouris, N. G.

AU - Alchanatis, M.

PY - 2012/5/31

Y1 - 2012/5/31

N2 - Exercise-induced dynamic hyperinflation and large intrathoracic pressure swings may compromise the normal increase in cardiac output (Q) in Chronic Obstructive Pulmonary Disease (COPD). Therefore, it is anticipated that the greater the disease severity, the greater would be the impairment in cardiac output during exercise. Eighty COPD patients (20 at each GOLD Stage) and 10 healthy age-matched individuals undertook a constant-load test on a cycle-ergometer (75% WRpeak) and a 6 min walking test (6MWT). Cardiac output was measured by bioimpedance (PhysioFlow, Enduro) to determine the mean response time at the onset of exercise (MRTon) and during recovery (MRToff). Whilst cardiac output mean response time was not different between the two exercise protocols, MRT responses during cycling were slower in GOLD Stages III and IV compared to Stages land II (MRTon: Stage 1:45 2, Stage II: 65 3, Stage 111: 90 3, Stage IV: 106 +/- 3 s; MRToff: Stage I: 42 +/- 2, Stage II: 68 +/- 3. Stage III: 87 +/- 3, Stage IV: 104 +/- 3 s, respectively). In conclusion, the more advanced the disease severity the more impaired is the hemodynamic response to constant-load exercise and the 6MWT, possibly reflecting greater cardiovascular impairment and/or greater physical deconditioning.

AB - Exercise-induced dynamic hyperinflation and large intrathoracic pressure swings may compromise the normal increase in cardiac output (Q) in Chronic Obstructive Pulmonary Disease (COPD). Therefore, it is anticipated that the greater the disease severity, the greater would be the impairment in cardiac output during exercise. Eighty COPD patients (20 at each GOLD Stage) and 10 healthy age-matched individuals undertook a constant-load test on a cycle-ergometer (75% WRpeak) and a 6 min walking test (6MWT). Cardiac output was measured by bioimpedance (PhysioFlow, Enduro) to determine the mean response time at the onset of exercise (MRTon) and during recovery (MRToff). Whilst cardiac output mean response time was not different between the two exercise protocols, MRT responses during cycling were slower in GOLD Stages III and IV compared to Stages land II (MRTon: Stage 1:45 2, Stage II: 65 3, Stage 111: 90 3, Stage IV: 106 +/- 3 s; MRToff: Stage I: 42 +/- 2, Stage II: 68 +/- 3. Stage III: 87 +/- 3, Stage IV: 104 +/- 3 s, respectively). In conclusion, the more advanced the disease severity the more impaired is the hemodynamic response to constant-load exercise and the 6MWT, possibly reflecting greater cardiovascular impairment and/or greater physical deconditioning.

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KW - COPD

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