Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome: insights from the RESOLVE study

Gaël Ennequin; Benjamin Buchard; Bruno Pereira; Line Bonjean; Daniel Courteix; Bruno Lesourd; Robert Chapier; Philippe Obert; Agnes Vinet; Guillaume Walther; Marek Zak; Reza Bagheri; Chris U. Ugbolue; Armand Abergel; Frédéric Dutheil; David Thivel

doi:10.23736/S2724-5985.22.03139-4

Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome: insights from the RESOLVE study

Gaël Ennequin
, Benjamin Buchard
, Bruno Pereira
, Line Bonjean
, Daniel Courteix
, Bruno Lesourd
, Robert Chapier
, Philippe Obert
, Agnes Vinet
, Guillaume Walther
, Marek Zak
, Reza Bagheri
, Chris U. Ugbolue
, Armand Abergel
, Frédéric Dutheil
, David Thivel

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: The aim of the present study was to evaluate i) the presence of liver steatosis using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI) and Liver Fat Score (LFS) in patients suffering from MS and ii) the association of FLI, HSI and LFS with the cardiometabolic risks.

METHODS: A total of 91 patients with MS (MS; 39 men, 52 women) and 44 age matched healthy subjects (Control; 23 men and 21 women) were enrolled in the study. A continuous cardiometabolic score (MetsScore) and the noninvasive tests of hepatic steatosis were calculated for comparison and association analysis.

RESULTS: Liver steatosis was detected in 86%, 84% and 80% of people diagnosed with MS using FLI, HSI and LFS respectively and MetsScore increases with FLI severity (p<0,05). Also, FLI and LFS were positively associated with MetsScore (p<0.01 and p<0.05 respectively) but not HSI. Multivariate linear regression models revealed that FLI has a stronger association with MetsScore compared with HSI and LFS (p<0,001).

CONCLUSIONS: FLI is associated with the severity of MS and represent a good indicator to assess the relation between liver steatosis and a cardiometabolic disorders in clinical routine.

Original language	English
Pages (from-to)	494-503
Number of pages	10
Journal	Minerva Gastroenterology
Volume	69
Issue number	4
Early online date	10 Feb 2022
DOIs	https://doi.org/10.23736/S2724-5985.22.03139-4
Publication status	Published - 31 Dec 2023

Keywords

metabolic syndrome
non-alcoholic fatty liver disease
fatty liver index
hepatic steatosis index
liver fat score

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10.23736/S2724-5985.22.03139-4

2022 02 01 Ennequin et al Biomarkers acceptedAccepted author manuscript, 294 KB

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Ennequin, G., Buchard, B., Pereira, B., Bonjean, L., Courteix, D., Lesourd, B., Chapier, R., Obert, P., Vinet, A., Walther, G., Zak, M., Bagheri, R., Ugbolue, C. U., Abergel, A., Dutheil, F., & Thivel, D. (2023). Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome: insights from the RESOLVE study. Minerva Gastroenterology, 69(4), 494-503. https://doi.org/10.23736/S2724-5985.22.03139-4

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title = "Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome: insights from the RESOLVE study",

abstract = "BACKGROUND: The aim of the present study was to evaluate i) the presence of liver steatosis using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI) and Liver Fat Score (LFS) in patients suffering from MS and ii) the association of FLI, HSI and LFS with the cardiometabolic risks. METHODS: A total of 91 patients with MS (MS; 39 men, 52 women) and 44 age matched healthy subjects (Control; 23 men and 21 women) were enrolled in the study. A continuous cardiometabolic score (MetsScore) and the noninvasive tests of hepatic steatosis were calculated for comparison and association analysis. RESULTS: Liver steatosis was detected in 86\%, 84\% and 80\% of people diagnosed with MS using FLI, HSI and LFS respectively and MetsScore increases with FLI severity (p<0,05). Also, FLI and LFS were positively associated with MetsScore (p<0.01 and p<0.05 respectively) but not HSI. Multivariate linear regression models revealed that FLI has a stronger association with MetsScore compared with HSI and LFS (p<0,001). CONCLUSIONS: FLI is associated with the severity of MS and represent a good indicator to assess the relation between liver steatosis and a cardiometabolic disorders in clinical routine. ",

keywords = "metabolic syndrome, non-alcoholic fatty liver disease, fatty liver index, hepatic steatosis index, liver fat score",

author = "Ga{\"e}l Ennequin and Benjamin Buchard and Bruno Pereira and Line Bonjean and Daniel Courteix and Bruno Lesourd and Robert Chapier and Philippe Obert and Agnes Vinet and Guillaume Walther and Marek Zak and Reza Bagheri and Ugbolue, \{Chris U.\} and Armand Abergel and Fr{\'e}d{\'e}ric Dutheil and David Thivel",

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month = dec,

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doi = "10.23736/S2724-5985.22.03139-4",

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Ennequin, G, Buchard, B, Pereira, B, Bonjean, L, Courteix, D, Lesourd, B, Chapier, R, Obert, P, Vinet, A, Walther, G, Zak, M, Bagheri, R, Ugbolue, CU, Abergel, A, Dutheil, F & Thivel, D 2023, 'Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome: insights from the RESOLVE study', Minerva Gastroenterology, vol. 69, no. 4, pp. 494-503. https://doi.org/10.23736/S2724-5985.22.03139-4

TY - JOUR

T1 - Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome

T2 - insights from the RESOLVE study

AU - Ennequin, Gaël

AU - Buchard, Benjamin

AU - Pereira, Bruno

AU - Bonjean, Line

AU - Courteix, Daniel

AU - Lesourd, Bruno

AU - Chapier, Robert

AU - Obert, Philippe

AU - Vinet, Agnes

AU - Walther, Guillaume

AU - Zak, Marek

AU - Bagheri, Reza

AU - Ugbolue, Chris U.

AU - Abergel, Armand

AU - Dutheil, Frédéric

AU - Thivel, David

PY - 2023/12/31

Y1 - 2023/12/31

N2 - BACKGROUND: The aim of the present study was to evaluate i) the presence of liver steatosis using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI) and Liver Fat Score (LFS) in patients suffering from MS and ii) the association of FLI, HSI and LFS with the cardiometabolic risks. METHODS: A total of 91 patients with MS (MS; 39 men, 52 women) and 44 age matched healthy subjects (Control; 23 men and 21 women) were enrolled in the study. A continuous cardiometabolic score (MetsScore) and the noninvasive tests of hepatic steatosis were calculated for comparison and association analysis. RESULTS: Liver steatosis was detected in 86%, 84% and 80% of people diagnosed with MS using FLI, HSI and LFS respectively and MetsScore increases with FLI severity (p<0,05). Also, FLI and LFS were positively associated with MetsScore (p<0.01 and p<0.05 respectively) but not HSI. Multivariate linear regression models revealed that FLI has a stronger association with MetsScore compared with HSI and LFS (p<0,001). CONCLUSIONS: FLI is associated with the severity of MS and represent a good indicator to assess the relation between liver steatosis and a cardiometabolic disorders in clinical routine.

AB - BACKGROUND: The aim of the present study was to evaluate i) the presence of liver steatosis using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI) and Liver Fat Score (LFS) in patients suffering from MS and ii) the association of FLI, HSI and LFS with the cardiometabolic risks. METHODS: A total of 91 patients with MS (MS; 39 men, 52 women) and 44 age matched healthy subjects (Control; 23 men and 21 women) were enrolled in the study. A continuous cardiometabolic score (MetsScore) and the noninvasive tests of hepatic steatosis were calculated for comparison and association analysis. RESULTS: Liver steatosis was detected in 86%, 84% and 80% of people diagnosed with MS using FLI, HSI and LFS respectively and MetsScore increases with FLI severity (p<0,05). Also, FLI and LFS were positively associated with MetsScore (p<0.01 and p<0.05 respectively) but not HSI. Multivariate linear regression models revealed that FLI has a stronger association with MetsScore compared with HSI and LFS (p<0,001). CONCLUSIONS: FLI is associated with the severity of MS and represent a good indicator to assess the relation between liver steatosis and a cardiometabolic disorders in clinical routine.

KW - metabolic syndrome

KW - non-alcoholic fatty liver disease

KW - fatty liver index

KW - hepatic steatosis index

KW - liver fat score

U2 - 10.23736/S2724-5985.22.03139-4

DO - 10.23736/S2724-5985.22.03139-4

M3 - Article

C2 - 35144365

SN - 1827-1642

VL - 69

SP - 494

EP - 503

JO - Minerva Gastroenterology

JF - Minerva Gastroenterology

IS - 4

ER -

Non-invasive biomarkers of non-alcoholic fatty liver disease in patients with Metabolic Syndrome: insights from the RESOLVE study

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Keywords

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