Non-Hodgkin's lymphomas complicating Sjögren's syndrome: can Epstein Barr virus be implicated?

M. Jeffers, A. Crilly, T. Kerr, J. Richmond, R. Madhok

Research output: Contribution to journalArticle

Abstract

We examined eight (6 parotid, 1 caecum, 1 lymph node) non Hodgkin's Lymphomas (NHL) complicating primary Sjögren's syndrome (SS), four parotid NHL, in patients without SS, and three salivary gland biopsies from SS patients and no NHL, for Epstein Barr virus (EBV), using immunohistochemistry for late membrane protein, in situ hybridisation (ISH) for EBER, and PCR for EBV DNA. Late membrane protein was not detected. In NHL's complicating SS, EBERs were detected in two parotid lymphomas by ISH. EBV DNA was detected in three SS parotid NHL. Cecal and lymph node SS NHL were negative for EBER and EBV DNA. EBV DNA was detected in two non SS NHLs, one expressed EBER. Despite positive EBV DNA results by PCR in three samples expression of EBER was noted in only one by ISH. This was a high grade NHL complicating SS. There was no evidence of EBV in low grade NHLs complicating SS.

Original languageEnglish
Pages (from-to)180-3
Number of pages4
JournalScandinavian Journal of Rheumatology
Volume26
Issue number3
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Human Herpesvirus 4
Non-Hodgkin's Lymphoma
DNA
In Situ Hybridization
Membrane Proteins
Lymph Nodes
Polymerase Chain Reaction
Salivary Glands
Lymphoma
Immunohistochemistry
Biopsy

Keywords

  • DNA Primers
  • DNA, Viral
  • Herpesviridae Infections
  • Herpesvirus 4, Human
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymph Nodes
  • Lymphoma, B-Cell, Marginal Zone
  • Lymphoma, Non-Hodgkin
  • Neck
  • Parotid Gland
  • Polymerase Chain Reaction
  • Sjogren's Syndrome
  • Tumor Virus Infections
  • Viral Matrix Proteins

Cite this

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title = "Non-Hodgkin's lymphomas complicating Sj{\"o}gren's syndrome: can Epstein Barr virus be implicated?",
abstract = "We examined eight (6 parotid, 1 caecum, 1 lymph node) non Hodgkin's Lymphomas (NHL) complicating primary Sj{\"o}gren's syndrome (SS), four parotid NHL, in patients without SS, and three salivary gland biopsies from SS patients and no NHL, for Epstein Barr virus (EBV), using immunohistochemistry for late membrane protein, in situ hybridisation (ISH) for EBER, and PCR for EBV DNA. Late membrane protein was not detected. In NHL's complicating SS, EBERs were detected in two parotid lymphomas by ISH. EBV DNA was detected in three SS parotid NHL. Cecal and lymph node SS NHL were negative for EBER and EBV DNA. EBV DNA was detected in two non SS NHLs, one expressed EBER. Despite positive EBV DNA results by PCR in three samples expression of EBER was noted in only one by ISH. This was a high grade NHL complicating SS. There was no evidence of EBV in low grade NHLs complicating SS.",
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Non-Hodgkin's lymphomas complicating Sjögren's syndrome : can Epstein Barr virus be implicated? / Jeffers, M.; Crilly, A.; Kerr, T.; Richmond, J.; Madhok, R.

In: Scandinavian Journal of Rheumatology, Vol. 26, No. 3, 1997, p. 180-3.

Research output: Contribution to journalArticle

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T1 - Non-Hodgkin's lymphomas complicating Sjögren's syndrome

T2 - can Epstein Barr virus be implicated?

AU - Jeffers, M.

AU - Crilly, A.

AU - Kerr, T.

AU - Richmond, J.

AU - Madhok, R.

PY - 1997

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N2 - We examined eight (6 parotid, 1 caecum, 1 lymph node) non Hodgkin's Lymphomas (NHL) complicating primary Sjögren's syndrome (SS), four parotid NHL, in patients without SS, and three salivary gland biopsies from SS patients and no NHL, for Epstein Barr virus (EBV), using immunohistochemistry for late membrane protein, in situ hybridisation (ISH) for EBER, and PCR for EBV DNA. Late membrane protein was not detected. In NHL's complicating SS, EBERs were detected in two parotid lymphomas by ISH. EBV DNA was detected in three SS parotid NHL. Cecal and lymph node SS NHL were negative for EBER and EBV DNA. EBV DNA was detected in two non SS NHLs, one expressed EBER. Despite positive EBV DNA results by PCR in three samples expression of EBER was noted in only one by ISH. This was a high grade NHL complicating SS. There was no evidence of EBV in low grade NHLs complicating SS.

AB - We examined eight (6 parotid, 1 caecum, 1 lymph node) non Hodgkin's Lymphomas (NHL) complicating primary Sjögren's syndrome (SS), four parotid NHL, in patients without SS, and three salivary gland biopsies from SS patients and no NHL, for Epstein Barr virus (EBV), using immunohistochemistry for late membrane protein, in situ hybridisation (ISH) for EBER, and PCR for EBV DNA. Late membrane protein was not detected. In NHL's complicating SS, EBERs were detected in two parotid lymphomas by ISH. EBV DNA was detected in three SS parotid NHL. Cecal and lymph node SS NHL were negative for EBER and EBV DNA. EBV DNA was detected in two non SS NHLs, one expressed EBER. Despite positive EBV DNA results by PCR in three samples expression of EBER was noted in only one by ISH. This was a high grade NHL complicating SS. There was no evidence of EBV in low grade NHLs complicating SS.

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KW - Herpesviridae Infections

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KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Lymph Nodes

KW - Lymphoma, B-Cell, Marginal Zone

KW - Lymphoma, Non-Hodgkin

KW - Neck

KW - Parotid Gland

KW - Polymerase Chain Reaction

KW - Sjogren's Syndrome

KW - Tumor Virus Infections

KW - Viral Matrix Proteins

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