New antiproliferative cembrane diterpenes from the Red Sea sarcophyton species

Hossam M. Hassan, Mostafa E. Rateb, Marwa H. Hassan, Ahmed M. Sayed, Samah Shabana, Mai Raslan, Elham Amin, Fathy A. Behery, Osama M. Ahmed, Abdullatif Bin Muhsinah, Tobias A.M. Gulder*, Usama Ramadan Abdelmohsen

*Corresponding author for this work

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Abstract

The combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral Sarcophyton sp. This approach facilitated the isolation of five new cembrane-type diterpenoids (1-5), along with two known analogs (6 and 7), as well as the identification of 19 further, known compounds. The chemical structures of the new compounds were elucidated while using comprehensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) NMR and HRMS. All of the isolated cembranoids (1-7) showed moderate in vitro antiproliferative activity against a human breast cancer cell line (MCF-7), with IC50 ranging from 22.39-27.12 µg/mL. This class of compounds could thus serve as scaffold for the future design of anticancer leads.

Original languageEnglish
Article number411
JournalMarine Drugs
Volume17
Issue number7
DOIs
Publication statusPublished - 11 Jul 2019

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Keywords

  • LCHRESMS
  • Dereplication
  • Cembranoids
  • Sarcophyton
  • Antiproliferative

Cite this

Hassan, H. M., Rateb, M. E., Hassan, M. H., Sayed, A. M., Shabana, S., Raslan, M., Amin, E., Behery, F. A., Ahmed, O. M., Bin Muhsinah, A., Gulder, T. A. M., & Ramadan Abdelmohsen, U. (2019). New antiproliferative cembrane diterpenes from the Red Sea sarcophyton species. Marine Drugs, 17(7), [411]. https://doi.org/10.3390/md17070411