Multi-wavelength ultrasonic standing wave device for non-invasive cell manipulation and characterisation

Yongqiang Qiu, Christine Démoré, Srikanta Sharma, Sandy Cochran, David A. Hughes, Kees Weijer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Ultrasonic standing wave manipulation has many promising applications in cell biology, such as noncontact investigation of cell and tissue mechanics. In this paper, recent progress in developing a high frequency resonant chamber using a lithium niobate transducer is presented. This device is designed to sit on a petri dish or microscope slide, with the propagation direction parallel to the dish surface, in a configuration compatible with an optical microscope. It comprises a high frequency ultrasonic transducer with a low acoustic impedance transducer mounting, a polished reflector, and a set of precision spacers between the reflector and transducer. The prototype device demonstrates the feasibility of trapping microparticles with ultrasound radiation forces in multiple trapping sites, and the short wavelength reduces the separation of trapping sites to the same order as the cell dimensions. The basic design of device was validated with one dimensional modelling and finite element simulation. Experimental results of trapping 10 μm polystyrene beads correspond to simulated pressure distributions showing multiples of half-wavelength standing waves.
Original languageEnglish
Title of host publication2011 IEEE International Ultrasonics Symposium
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages188-191
Number of pages4
ISBN (Print)9781457712531
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event2011 IEEE International Ultrasonics Symposium - Caribe Royale, Orlando , United States
Duration: 18 Oct 201121 Oct 2011

Publication series

NameUltrasonics Symposium
PublisherIEEE
ISSN (Print)1051-0117

Conference

Conference2011 IEEE International Ultrasonics Symposium
Country/TerritoryUnited States
CityOrlando
Period18/10/1121/10/11

Keywords

  • Ultrasound
  • Standing wave
  • Cell manipulation
  • High Frequency Transducer
  • Lithium Niobate

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