Monitoring performance of nucleic acid-based diagnostic measurement system users by EQA

H. J. Staines; L. Garcia-Fernandez; R. Pogothata; P. S. Wallace; W. G. MacKay; A. M. Van Loon

doi:10.1007/s00769-009-0510-2

Monitoring performance of nucleic acid-based diagnostic measurement system users by EQA

H. J. Staines, L. Garcia-Fernandez, R. Pogothata, P. S. Wallace, W. G. MacKay, A. M. Van Loon

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

External quality assurance (EQA) programmes allow a laboratory to monitor independently its performance and provide feedback to identify and investigate potential areas of concern. However, both the definition of appropriate 'performance indicators' and their statistical analysis vary across EQA providers. Typically, performance scores have an unknown statistical distribution and hence arbitrary thresholds are used to measure performance. In this paper, we introduce a scoring system based on well-known statistical principles. The system is simple, flexible and easy to interpret. It can be used to measure performance for single samples or across a panel so providing useful and meaningful information to participants in EQA programmes. The score is illustrated using the 2005 QCMD Hepatitis B Virus Proficiency programme.

Original language	English
Pages (from-to)	243-252
Number of pages	10
Journal	Accreditation and Quality Assurance
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/s00769-009-0510-2
Publication status	Published - May 2009
Externally published	Yes

Keywords

Quality assessment
Scoring system
Nucleic acid-based diagnostics
Proficiency test data
Statistical methods
Bayesian model

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00769-009-0510-2Licence: CC BY-NC

Cite this

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AU - Staines, H. J.

AU - Garcia-Fernandez, L.

AU - Pogothata, R.

AU - Wallace, P. S.

AU - MacKay, W. G.

AU - Van Loon, A. M.

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AB - External quality assurance (EQA) programmes allow a laboratory to monitor independently its performance and provide feedback to identify and investigate potential areas of concern. However, both the definition of appropriate 'performance indicators' and their statistical analysis vary across EQA providers. Typically, performance scores have an unknown statistical distribution and hence arbitrary thresholds are used to measure performance. In this paper, we introduce a scoring system based on well-known statistical principles. The system is simple, flexible and easy to interpret. It can be used to measure performance for single samples or across a panel so providing useful and meaningful information to participants in EQA programmes. The score is illustrated using the 2005 QCMD Hepatitis B Virus Proficiency programme.

KW - Quality assessment

KW - Scoring system

KW - Nucleic acid-based diagnostics

KW - Proficiency test data

KW - Statistical methods

KW - Bayesian model

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DO - 10.1007/s00769-009-0510-2

M3 - Article

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VL - 14

SP - 243

EP - 252

JO - Accreditation and Quality Assurance

JF - Accreditation and Quality Assurance

IS - 5

ER -

Monitoring performance of nucleic acid-based diagnostic measurement system users by EQA

Abstract

Keywords

UN SDGs

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