Molecular self-assembly and applications of designer peptide amphiphiles

Xiubo Zhao, Fang Pan, Hai Xu, Mohammed Yaseen, Honghong Shan, Charlotte A. E. Hauser, Shuguang Zhang, Jian R. Lu

Research output: Contribution to journalArticle

Abstract

Short synthetic peptide amphiphiles have recently been explored as effective nanobiomaterials in applications ranging from controlled gene and drug release, skin care, nanofabrication, biomineralization, membrane protein stabilization to 3D cell culture and tissue engineering. This range of applications is heavily linked to their unique nanostructures, remarkable simplicity and biocompatibility. Some peptide amphiphiles also possess antimicrobial activities whilst remaining benign to mammalian cells. These attractive features are inherently related to their selective affinity to different membrane interfaces, high capacity for interfacial adsorption, nanostructuring and spontaneous formation of nano-assemblies. Apart from sizes, the primary sequences of short peptides are very diverse as they can be either biomimetic or de novo designed. Thus, their self-assembling mechanistic processes and the nanostructures also vary enormously. This critical review highlights recent advances in studying peptide amphiphiles, focusing on the formation of different nanostructures and their applications in diverse fields. Many interesting features learned from peptide self-organisation and hierarchical templating will serve as useful guidance for functional materials design and nanobiotechnology (123 references).
Original languageEnglish
Pages (from-to)3480-3498
Number of pages19
JournalChem Soc Rev
Volume39
Issue number9
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this

Zhao, X., Pan, F., Xu, H., Yaseen, M., Shan, H., Hauser, C. A. E., ... Lu, J. R. (2010). Molecular self-assembly and applications of designer peptide amphiphiles. Chem Soc Rev, 39(9), 3480-3498. https://doi.org/10.1039/b915923c
Zhao, Xiubo ; Pan, Fang ; Xu, Hai ; Yaseen, Mohammed ; Shan, Honghong ; Hauser, Charlotte A. E. ; Zhang, Shuguang ; Lu, Jian R. / Molecular self-assembly and applications of designer peptide amphiphiles. In: Chem Soc Rev. 2010 ; Vol. 39, No. 9. pp. 3480-3498.
@article{7651999b1b51409d802cdc6f36d603bb,
title = "Molecular self-assembly and applications of designer peptide amphiphiles",
abstract = "Short synthetic peptide amphiphiles have recently been explored as effective nanobiomaterials in applications ranging from controlled gene and drug release, skin care, nanofabrication, biomineralization, membrane protein stabilization to 3D cell culture and tissue engineering. This range of applications is heavily linked to their unique nanostructures, remarkable simplicity and biocompatibility. Some peptide amphiphiles also possess antimicrobial activities whilst remaining benign to mammalian cells. These attractive features are inherently related to their selective affinity to different membrane interfaces, high capacity for interfacial adsorption, nanostructuring and spontaneous formation of nano-assemblies. Apart from sizes, the primary sequences of short peptides are very diverse as they can be either biomimetic or de novo designed. Thus, their self-assembling mechanistic processes and the nanostructures also vary enormously. This critical review highlights recent advances in studying peptide amphiphiles, focusing on the formation of different nanostructures and their applications in diverse fields. Many interesting features learned from peptide self-organisation and hierarchical templating will serve as useful guidance for functional materials design and nanobiotechnology (123 references).",
author = "Xiubo Zhao and Fang Pan and Hai Xu and Mohammed Yaseen and Honghong Shan and Hauser, {Charlotte A. E.} and Shuguang Zhang and Lu, {Jian R.}",
year = "2010",
doi = "10.1039/b915923c",
language = "English",
volume = "39",
pages = "3480--3498",
journal = "Chem Soc Rev",
issn = "0306-0012",
publisher = "Royal Society of Chemistry",
number = "9",

}

Zhao, X, Pan, F, Xu, H, Yaseen, M, Shan, H, Hauser, CAE, Zhang, S & Lu, JR 2010, 'Molecular self-assembly and applications of designer peptide amphiphiles' Chem Soc Rev, vol. 39, no. 9, pp. 3480-3498. https://doi.org/10.1039/b915923c

Molecular self-assembly and applications of designer peptide amphiphiles. / Zhao, Xiubo; Pan, Fang; Xu, Hai; Yaseen, Mohammed; Shan, Honghong; Hauser, Charlotte A. E.; Zhang, Shuguang; Lu, Jian R.

In: Chem Soc Rev, Vol. 39, No. 9, 2010, p. 3480-3498.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Molecular self-assembly and applications of designer peptide amphiphiles

AU - Zhao, Xiubo

AU - Pan, Fang

AU - Xu, Hai

AU - Yaseen, Mohammed

AU - Shan, Honghong

AU - Hauser, Charlotte A. E.

AU - Zhang, Shuguang

AU - Lu, Jian R.

PY - 2010

Y1 - 2010

N2 - Short synthetic peptide amphiphiles have recently been explored as effective nanobiomaterials in applications ranging from controlled gene and drug release, skin care, nanofabrication, biomineralization, membrane protein stabilization to 3D cell culture and tissue engineering. This range of applications is heavily linked to their unique nanostructures, remarkable simplicity and biocompatibility. Some peptide amphiphiles also possess antimicrobial activities whilst remaining benign to mammalian cells. These attractive features are inherently related to their selective affinity to different membrane interfaces, high capacity for interfacial adsorption, nanostructuring and spontaneous formation of nano-assemblies. Apart from sizes, the primary sequences of short peptides are very diverse as they can be either biomimetic or de novo designed. Thus, their self-assembling mechanistic processes and the nanostructures also vary enormously. This critical review highlights recent advances in studying peptide amphiphiles, focusing on the formation of different nanostructures and their applications in diverse fields. Many interesting features learned from peptide self-organisation and hierarchical templating will serve as useful guidance for functional materials design and nanobiotechnology (123 references).

AB - Short synthetic peptide amphiphiles have recently been explored as effective nanobiomaterials in applications ranging from controlled gene and drug release, skin care, nanofabrication, biomineralization, membrane protein stabilization to 3D cell culture and tissue engineering. This range of applications is heavily linked to their unique nanostructures, remarkable simplicity and biocompatibility. Some peptide amphiphiles also possess antimicrobial activities whilst remaining benign to mammalian cells. These attractive features are inherently related to their selective affinity to different membrane interfaces, high capacity for interfacial adsorption, nanostructuring and spontaneous formation of nano-assemblies. Apart from sizes, the primary sequences of short peptides are very diverse as they can be either biomimetic or de novo designed. Thus, their self-assembling mechanistic processes and the nanostructures also vary enormously. This critical review highlights recent advances in studying peptide amphiphiles, focusing on the formation of different nanostructures and their applications in diverse fields. Many interesting features learned from peptide self-organisation and hierarchical templating will serve as useful guidance for functional materials design and nanobiotechnology (123 references).

U2 - 10.1039/b915923c

DO - 10.1039/b915923c

M3 - Article

VL - 39

SP - 3480

EP - 3498

JO - Chem Soc Rev

JF - Chem Soc Rev

SN - 0306-0012

IS - 9

ER -