Minding the gap between theory and clinical practice: an individualised approach to the management of feline diabetes mellitus

Moira Lewitt, Emma Strage, David Church

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction
Insulin independence is a realistic therapeutic goal in feline diabetes. Remission is dependent on achieving fast glycemic control. However, without intensive monitoring high insulin doses increase the risk of hypoglycemia. An
11-year old spayed Burmese cat presented with diabetes after steroid treatment for skin allergy. Control of blood glucose was not achieved using low carbohydrate diet plus the recommended q12h treatment with either insulin lente or glargine, with the total dose limited by the risk of hypoglycaemia.

Objectives
The aim was to achieve euglycaemia and insulinindependence.

Methods
A more frequent insulin treatment was tried. Seven weeks from start of q12h treatment, the total daily dose of insulin glargine was divided across three injections. One week later the frequency of injection was increased to q6h. There was intensive monitoring of capillary blood glucose (Accu-Chek Aviva).

Results
There was a prominent glucose nadir after approximately 4h regardless of insulin type. Within four weeks on insulin q8h and q6h blood glucose levels were within the normal range. Weight gain was noted and within one week
of caloric restriction insulin was withdrawn completely. One month later fructosamine had normalized and after more than three years the cat remains off insulin with blood glucose levels at the upper limit of the reference
range.

Conclusions
More frequent insulin injections than recommended in literature may be necessary to achieve glycemic control. Owners are important collaborators in feline diabetes care and with intensive home monitoring more frequent insulin treatment may lead to remission without hypoglycemia
Original languageEnglish
Title of host publicationActa Veterinaria Scandinavica
PublisherBioMed Central
Number of pages1
Volume57 (Supplement 1)
DOIs
Publication statusPublished - 25 Sep 2015
EventAnimal Obesity: causes, consequences and comparative aspects - Uppsala, Sweden
Duration: 14 Jun 201516 Jun 2015
https://www.slu.se/en/Collaborative-Centres-and-Projects/future-animal-health-and-welfare/activities/animalobesity/

Publication series

NameActa Veterinaria Scandinavica
PublisherBioMed Central
Numbersupp. 1
Volume57
ISSN (Electronic)1751-0147

Conference

ConferenceAnimal Obesity
CountrySweden
CityUppsala
Period14/06/1516/06/15
Internet address

Fingerprint

Felidae
Diabetes Mellitus
Insulin
Blood Glucose
Hypoglycemia
Injections
Lente Insulin
Cats
Therapeutics
Carbohydrate-Restricted Diet
Fructosamine
Caloric Restriction
Critical Care
Weight Gain
Hypersensitivity
Reference Values
Steroids
Glucose
Skin

Keywords

  • blood glucose level
  • hypoglycemia
  • glycemic control
  • caloric restriction
  • insulin glargine

Cite this

Lewitt, M., Strage, E., & Church, D. (2015). Minding the gap between theory and clinical practice: an individualised approach to the management of feline diabetes mellitus. In Acta Veterinaria Scandinavica (Vol. 57 (Supplement 1)). (Acta Veterinaria Scandinavica; Vol. 57, No. supp. 1). BioMed Central. https://doi.org/10.1186/1751-0147-57-S1-P6
Lewitt, Moira ; Strage, Emma ; Church, David. / Minding the gap between theory and clinical practice : an individualised approach to the management of feline diabetes mellitus. Acta Veterinaria Scandinavica. Vol. 57 (Supplement 1) BioMed Central, 2015. (Acta Veterinaria Scandinavica; supp. 1).
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Lewitt, M, Strage, E & Church, D 2015, Minding the gap between theory and clinical practice: an individualised approach to the management of feline diabetes mellitus. in Acta Veterinaria Scandinavica. vol. 57 (Supplement 1), Acta Veterinaria Scandinavica, no. supp. 1, vol. 57, BioMed Central, Animal Obesity, Uppsala, Sweden, 14/06/15. https://doi.org/10.1186/1751-0147-57-S1-P6

Minding the gap between theory and clinical practice : an individualised approach to the management of feline diabetes mellitus. / Lewitt, Moira; Strage, Emma; Church, David.

Acta Veterinaria Scandinavica. Vol. 57 (Supplement 1) BioMed Central, 2015. (Acta Veterinaria Scandinavica; Vol. 57, No. supp. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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PY - 2015/9/25

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N2 - IntroductionInsulin independence is a realistic therapeutic goal in feline diabetes. Remission is dependent on achieving fast glycemic control. However, without intensive monitoring high insulin doses increase the risk of hypoglycemia. An11-year old spayed Burmese cat presented with diabetes after steroid treatment for skin allergy. Control of blood glucose was not achieved using low carbohydrate diet plus the recommended q12h treatment with either insulin lente or glargine, with the total dose limited by the risk of hypoglycaemia.ObjectivesThe aim was to achieve euglycaemia and insulinindependence.MethodsA more frequent insulin treatment was tried. Seven weeks from start of q12h treatment, the total daily dose of insulin glargine was divided across three injections. One week later the frequency of injection was increased to q6h. There was intensive monitoring of capillary blood glucose (Accu-Chek Aviva).ResultsThere was a prominent glucose nadir after approximately 4h regardless of insulin type. Within four weeks on insulin q8h and q6h blood glucose levels were within the normal range. Weight gain was noted and within one weekof caloric restriction insulin was withdrawn completely. One month later fructosamine had normalized and after more than three years the cat remains off insulin with blood glucose levels at the upper limit of the referencerange.ConclusionsMore frequent insulin injections than recommended in literature may be necessary to achieve glycemic control. Owners are important collaborators in feline diabetes care and with intensive home monitoring more frequent insulin treatment may lead to remission without hypoglycemia

AB - IntroductionInsulin independence is a realistic therapeutic goal in feline diabetes. Remission is dependent on achieving fast glycemic control. However, without intensive monitoring high insulin doses increase the risk of hypoglycemia. An11-year old spayed Burmese cat presented with diabetes after steroid treatment for skin allergy. Control of blood glucose was not achieved using low carbohydrate diet plus the recommended q12h treatment with either insulin lente or glargine, with the total dose limited by the risk of hypoglycaemia.ObjectivesThe aim was to achieve euglycaemia and insulinindependence.MethodsA more frequent insulin treatment was tried. Seven weeks from start of q12h treatment, the total daily dose of insulin glargine was divided across three injections. One week later the frequency of injection was increased to q6h. There was intensive monitoring of capillary blood glucose (Accu-Chek Aviva).ResultsThere was a prominent glucose nadir after approximately 4h regardless of insulin type. Within four weeks on insulin q8h and q6h blood glucose levels were within the normal range. Weight gain was noted and within one weekof caloric restriction insulin was withdrawn completely. One month later fructosamine had normalized and after more than three years the cat remains off insulin with blood glucose levels at the upper limit of the referencerange.ConclusionsMore frequent insulin injections than recommended in literature may be necessary to achieve glycemic control. Owners are important collaborators in feline diabetes care and with intensive home monitoring more frequent insulin treatment may lead to remission without hypoglycemia

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DO - 10.1186/1751-0147-57-S1-P6

M3 - Conference contribution

VL - 57 (Supplement 1)

T3 - Acta Veterinaria Scandinavica

BT - Acta Veterinaria Scandinavica

PB - BioMed Central

ER -

Lewitt M, Strage E, Church D. Minding the gap between theory and clinical practice: an individualised approach to the management of feline diabetes mellitus. In Acta Veterinaria Scandinavica. Vol. 57 (Supplement 1). BioMed Central. 2015. (Acta Veterinaria Scandinavica; supp. 1). https://doi.org/10.1186/1751-0147-57-S1-P6